GenAge entry for SUMO1 (Homo sapiens)

Gene name (HAGRID: 211)

HGNC symbol: SUMO1
Aliases: PIC1; GMP1; SMT3C; SUMO-1; SMT3H3; OFC10; UBL1
Common name: small ubiquitin-like modifier 1

Potential relevance to the human ageing process

Main reason for selection: Entry selected based on evidence linking the gene product to the regulation or control of genes previously linked to ageing
Description: SUMO1 is a small protein that interacts with several partners and hence is related to many processes, including DNA repair and signal transduction. It may be related to WRN [903]. There is no evidence associating SUMO1 with ageing, though because of its many functions it is possible that SUMO1 has some impact on human ageing.

Cytogenetic information

Cytogenetic band: 2q33
Location: 202,206,180 bp to 202,238,599 bp
Orientation: Minus strand

Display region using the UCSC Genome Browser (GRCh38/hg38)

Protein information

Gene Ontology

Process:

GO:0006281; DNA repair
GO:0006303; double-strand break repair via nonhomologous end joining
GO:0016032; viral process
GO:0016925; protein sumoylation
GO:0030578; PML body organization
GO:0031334; positive regulation of protein complex assembly
GO:0032436; positive regulation of proteasomal ubiquitin-dependent protein catabolic process
GO:0032880; regulation of protein localization
GO:0034605; cellular response to heat
GO:0043392; negative regulation of DNA binding
GO:0043433; negative regulation of sequence-specific DNA binding transcription factor activity
GO:0045759; negative regulation of action potential
GO:0045892; negative regulation of transcription, DNA-templated
GO:0050821; protein stabilization
GO:0060021; palate development
GO:0060334; regulation of interferon-gamma-mediated signaling pathway
GO:0070911; global genome nucleotide-excision repair
GO:0071276; cellular response to cadmium ion
GO:0086004; regulation of cardiac muscle cell contraction
GO:0090204; protein localization to nuclear pore
GO:1901896; positive regulation of calcium-transporting ATPase activity
GO:1902260; negative regulation of delayed rectifier potassium channel activity

Cellular component:

GO:0000792; heterochromatin
GO:0001650; fibrillar center
GO:0001741; XY body
GO:0005634; nucleus
GO:0005643; nuclear pore
GO:0005654; nucleoplasm
GO:0005730; nucleolus
GO:0005737; cytoplasm
GO:0005886; plasma membrane
GO:0008076; voltage-gated potassium channel complex
GO:0016604; nuclear body
GO:0016605; PML body
GO:0016607; nuclear speck
GO:0030425; dendrite
GO:0031965; nuclear membrane
GO:0045202; synapse
GO:0097165; nuclear stress granule

Function:

GO:0005515; protein binding
GO:0008134; transcription factor binding
GO:0015459; potassium channel regulator activity
GO:0031386; protein tag
GO:0031625; ubiquitin protein ligase binding
GO:0044325; ion channel binding
GO:0044822; poly(A) RNA binding

Hide GO terms

Protein interactions and network

Protein-protein interacting partners in GenAge: TP53, WRN, BRCA1, CREBBP, BLM, VCP, NR3C1, TOP2B, RAD51, UBE2I, PML, FAS, FOXM1, RAD52, JUN, ATF2, BUB1B, PTGS2, MDM2, SUMO1, MTOR, TP63, NCOR2, TP73, NFE2L2
STRING interaction network

Retrieve sequences for SUMO1

Promoter: Promoter
ORF: ORF
CDS: CDS

Homologs in model organisms

Caenorhabditis elegans: smo-1
Danio rerio: sumo1
Mus musculus: Sumo1
Rattus norvegicus: Sumo1
Schizosaccharomyces pombe: pmt3