GenAge entry for TP73 (Homo sapiens)

Gene name (HAGRID: 281)

HGNC symbol: TP73
Aliases: P73
Common name: tumor protein p73

Potential relevance to the human ageing process

Main reason for selection: Entry selected based on evidence linking the gene product to a pathway or mechanism linked to ageing
Description: The tumor suppressor TP73 encodes a member of the p53 family of transcription factors involved in cellular responses to stress and participates in the apoptotic response to DNA damage. Compared to p53-deficient mice, p73-deficient mice also exhibited profound defects, including hippocampal dysgenesis, hydrocephalus, chronic infections and inflammation, as well as abnormalities in pheromone sensory pathways, but showed no increased susceptibility to spontaneous tumorigenesis [2203]. Old p73 +/- mice are more susceptible to neurodegeneration and showed decreased cognitive and motor function, brain atrophy, and neuronal degeneration compared to wild type [2204]. Mice lacking one of the isoforms (DeltaNp73) are viable and fertile but display the signs of neurodegeneration. Cells from these mice are more sensible to DNA-damage and have an increased p53-dependent apoptosis [2205]. Therefore, it is possible that TP73 plays a role in some aspects of ageing, in particular in the brain.

Cytogenetic information

Cytogenetic band: 1p36.3
Location: 3,698,046 bp to 3,736,201 bp
Orientation: Plus strand

Display region using the UCSC Genome Browser (GRCh38/hg38)

Protein information

Gene Ontology

Process:

GO:0000122; negative regulation of transcription from RNA polymerase II promoter
GO:0000187; activation of MAPK activity
GO:0001822; kidney development
GO:0006298; mismatch repair
GO:0006366; transcription from RNA polymerase II promoter
GO:0006974; cellular response to DNA damage stimulus
GO:0006978; DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator
GO:0007050; cell cycle arrest
GO:0007346; regulation of mitotic cell cycle
GO:0008630; intrinsic apoptotic signaling pathway in response to DNA damage
GO:0010165; response to X-ray

And 21 more GO terms

Cellular component:

GO:0000785; chromatin
GO:0005634; nucleus
GO:0005654; nucleoplasm
GO:0005667; transcription factor complex
GO:0005739; mitochondrion
GO:0005794; Golgi apparatus
GO:0005829; cytosol
GO:0030054; cell junction
GO:0043231; intracellular membrane-bounded organelle

Function:

GO:0000978; RNA polymerase II core promoter proximal region sequence-specific DNA binding
GO:0000981; RNA polymerase II transcription factor activity, sequence-specific DNA binding
GO:0001077; transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding
GO:0002039; p53 binding
GO:0003682; chromatin binding
GO:0003684; damaged DNA binding
GO:0003700; transcription factor activity, sequence-specific DNA binding
GO:0005515; protein binding
GO:0008134; transcription factor binding
GO:0019901; protein kinase binding
GO:0042802; identical protein binding

And 3 more GO terms

Show all GO terms

Protein interactions and network

Protein-protein interacting partners in GenAge: TP53, MYC, BRCA1, PIN1, CREBBP, ABL1, UBE2I, EP300, RB1, SIRT1, HDAC1, HSPA9, HMGB1, CCNA2, BUB1B, HDAC2, MDM2, SUMO1, TP53BP1, TP73, IKBKB
STRING interaction network

Retrieve sequences for TP73

ORF: ORF
CDS: CDS

Homologs in model organisms

Danio rerio: tp73
Mus musculus: Tp73
Rattus norvegicus: Tp73

In other databases

GenAge model organism genes

A homolog of this gene for Mus musculus is present as Trp73