GenAge entry for RAD52 (Homo sapiens)

Gene name (HAGRID: 147)

HGNC symbol: RAD52
Aliases
Common name: RAD52 homolog, DNA repair protein

Potential relevance to the human ageing process

Main reason for selection: Entry selected based on evidence directly linking the gene product to ageing in a cellular model system
Description: RAD52 is involved in DNA repair and appears to interact with WRN [727]. It has been reported to be an important player in the cellular senescence of yeast [192]. Its role, if any, in mammalian ageing remains elusive.

Cytogenetic information

Cytogenetic band: 12p13-p12.
Location: 912,077 bp to 990,053 bp
Orientation: Minus strand

Display region using the UCSC Genome Browser (GRCh38/hg38)

Protein information

Gene Ontology

Process:

GO:0000730; DNA recombinase assembly
GO:0006302; double-strand break repair
GO:0006310; DNA recombination
GO:0006974; cellular response to DNA damage stimulus
GO:0010792; DNA double-strand break processing involved in repair via single-strand annealing
GO:0016925; protein sumoylation
GO:0034599; cellular response to oxidative stress
GO:2000819; regulation of nucleotide-excision repair

Cellular component:

GO:0005634; nucleus
GO:0005654; nucleoplasm
GO:0043234; protein complex

Function:

GO:0003677; DNA binding
GO:0005515; protein binding
GO:0042802; identical protein binding

Show all GO terms

Protein interactions and network

Protein-protein interacting partners in GenAge: ERCC2, WRN, RPA1, HSP90AA1, RAD51, UBE2I, ERCC3, PRDX1, RAD52, HSPD1, YWHAZ, EEF1A1, HSPA8, SUMO1
STRING interaction network

Retrieve sequences for RAD52

ORF: ORF
CDS: CDS

Homologs in model organisms

Danio rerio: rad52
Mus musculus: Rad52
Rattus norvegicus: Rad52

In other databases

LongevityMap

This gene is present as RAD52