GenAge entry for TOP2A (Homo sapiens)

Gene name (HAGRID: 80)

HGNC symbol: TOP2A
Aliases: TOP2
Common name: topoisomerase (DNA) II alpha

Potential relevance to the human ageing process

Main reason for selection: Entry selected based on evidence linking the gene product to a pathway or mechanism linked to ageing
Description: Topoisomerases regulate the topological states of DNA [483]. Though no direct interaction has been reported, TOP2A has been indirectly linked to WRN [61] and ATM [482]. TOP2A has also been suggested as an important player in neuron proliferation [483]. Because TOP2A has been associated with several DNA metabolism proteins thought to play a role in ageing, it is possible that TOP2A itself is involved in human ageing, though further studies are necessary to confirm this hypothesis.

Cytogenetic information

Cytogenetic band: 17q21-q22
Location: 40,388,521 bp to 40,417,950 bp
Orientation: Minus strand

Display region using the UCSC Genome Browser (GRCh38/hg38)

Protein information

Gene Ontology

Process:

GO:0000712; resolution of meiotic recombination intermediates
GO:0000819; sister chromatid segregation
GO:0002244; hematopoietic progenitor cell differentiation
GO:0006265; DNA topological change
GO:0006266; DNA ligation
GO:0006268; DNA unwinding involved in DNA replication
GO:0006312; mitotic recombination
GO:0006974; cellular response to DNA damage stimulus
GO:0007059; chromosome segregation
GO:0016925; protein sumoylation
GO:0030263; apoptotic chromosome condensation
GO:0040016; embryonic cleavage
GO:0042752; regulation of circadian rhythm
GO:0043065; positive regulation of apoptotic process
GO:0044774; mitotic DNA integrity checkpoint
GO:0045070; positive regulation of viral genome replication
GO:0045870; positive regulation of single stranded viral RNA replication via double stranded DNA intermediate
GO:0045944; positive regulation of transcription from RNA polymerase II promoter
GO:0048511; rhythmic process

Cellular component:

GO:0000228; nuclear chromosome
GO:0000793; condensed chromosome
GO:0005634; nucleus
GO:0005654; nucleoplasm
GO:0005730; nucleolus
GO:0005814; centriole
GO:0009295; nucleoid
GO:0009330; DNA topoisomerase complex (ATP-hydrolyzing)
GO:0019035; viral integration complex
GO:0043234; protein complex

Function:

GO:0000287; magnesium ion binding
GO:0003677; DNA binding
GO:0003682; chromatin binding
GO:0003918; DNA topoisomerase type II (ATP-hydrolyzing) activity
GO:0005080; protein kinase C binding
GO:0005515; protein binding
GO:0005524; ATP binding
GO:0008022; protein C-terminus binding
GO:0008094; DNA-dependent ATPase activity
GO:0008144; drug binding
GO:0008301; DNA binding, bending
GO:0019899; enzyme binding
GO:0042803; protein homodimerization activity
GO:0042826; histone deacetylase binding
GO:0043130; ubiquitin binding
GO:0044822; poly(A) RNA binding
GO:0046982; protein heterodimerization activity

Hide GO terms

Protein interactions and network

Protein-protein interacting partners in GenAge: TP53, LMNA, MYC, BRCA1, PIN1, RPA1, BLM, TOP2B, TOP1, UBE2I, GSK3B, PRKCA, XRCC5, TERF2, RB1, HDAC1, JUN, BMI1, HDAC2, ESR1, CTNNB1
STRING interaction network

Retrieve sequences for TOP2A

ORF: ORF
CDS: CDS

Homologs in model organisms

Mus musculus: Top2a
Rattus norvegicus: Top2a

In other databases

CellAge gene expression

This gene is present as TOP2A