GenAge entry for TOP2B (Homo sapiens)

Gene name (HAGRID: 81)

HGNC symbol: TOP2B
Aliases
Common name: topoisomerase (DNA) II beta

Potential relevance to the human ageing process

Main reason for selection: Entry selected based on evidence linking the gene product to a pathway or mechanism linked to ageing
Description: Topoisomerases regulate the topological states of DNA [483]. Though no direct interaction has been reported, TOP2B has been indirectly linked to WRN [61] and ATM [482]. TOP2B has also been suggested as an important player in neuron proliferation [483]. Because TOP2B has been associated with several DNA metabolism proteins thought to play a role in ageing, it is possible that TOP2B is itself involved in human ageing, though further studies are necessary to confirm this hypothesis.

Cytogenetic information

Cytogenetic band: 3p24
Location: 25,597,905 bp to 25,664,372 bp
Orientation: Minus strand

Display region using the UCSC Genome Browser (GRCh38/hg38)

Protein information

Gene Ontology

Process:

GO:0000712; resolution of meiotic recombination intermediates
GO:0000819; sister chromatid segregation
GO:0001764; neuron migration
GO:0006265; DNA topological change
GO:0006268; DNA unwinding involved in DNA replication
GO:0006312; mitotic recombination
GO:0007409; axonogenesis
GO:0016925; protein sumoylation
GO:0030900; forebrain development
GO:0044774; mitotic DNA integrity checkpoint

Cellular component:

GO:0000792; heterochromatin
GO:0005634; nucleus
GO:0005654; nucleoplasm
GO:0005730; nucleolus
GO:0005737; cytoplasm
GO:0005829; cytosol
GO:0009295; nucleoid
GO:0009330; DNA topoisomerase complex (ATP-hydrolyzing)

Function:

GO:0003682; chromatin binding
GO:0003918; DNA topoisomerase type II (ATP-hydrolyzing) activity
GO:0005080; protein kinase C binding
GO:0005524; ATP binding
GO:0008022; protein C-terminus binding
GO:0008301; DNA binding, bending
GO:0019899; enzyme binding
GO:0042826; histone deacetylase binding
GO:0046872; metal ion binding
GO:0046982; protein heterodimerization activity

Hide GO terms

Protein interactions and network

Protein-protein interacting partners in GenAge: TP53, HDAC3, PARP1, RPA1, TOP2A, TOP1, UBE2I, PML, HDAC1, HDAC2, SUMO1, ESR1
STRING interaction network

Retrieve sequences for TOP2B

ORF: ORF
CDS: CDS

Homologs in model organisms

Caenorhabditis elegans: K12D12.1
Danio rerio: top2b
Drosophila melanogaster: Top2
Mus musculus: Top2b
Saccharomyces cerevisiae: TOP2
Schizosaccharomyces pombe: top2