GenAge entry for TXN (Homo sapiens)

Gene name (HAGRID: 16)

HGNC symbol: TXN
Aliases: TRX
Common name: thioredoxin

Potential relevance to the human ageing process

Main reason for selection: Entry selected based on evidence directly linking the gene product to ageing in a non-mammalian animal model
Description: TXN plays a role in regulating the cellular redox status. Some evidence also indicates TXN is a growth-suppressor [242]. TXN overexpression in the neurons of flies extended the mean lifespan by 15% [1931]. Its overexpression in mice increases lifespan, but it is not known whether the ageing process is affected [19]. Another study found no overall effects on lifespan of overexpression in mice, although it could be beneficial in the earlier part of life [1959]. As such, its role in human ageing remains unclear.

Cytogenetic information

Cytogenetic band: 9q31
Location: 110,243,812 bp to 110,256,640 bp
Orientation: Minus strand

Display region using the UCSC Genome Browser (GRCh38/hg38)

Protein information

Gene Ontology

Process:

GO:0000122; negative regulation of transcription from RNA polymerase II promoter
GO:0000302; response to reactive oxygen species
GO:0006351; transcription, DNA-templated
GO:0006662; glycerol ether metabolic process
GO:0006928; movement of cell or subcellular component
GO:0007165; signal transduction
GO:0007267; cell-cell signaling
GO:0008283; cell proliferation
GO:0009314; response to radiation
GO:0015949; nucleobase-containing small molecule interconversion
GO:0030091; protein repair
GO:0032148; activation of protein kinase B activity
GO:0033138; positive regulation of peptidyl-serine phosphorylation
GO:0033158; regulation of protein import into nucleus, translocation
GO:0043388; positive regulation of DNA binding
GO:0045454; cell redox homeostasis
GO:0046826; negative regulation of protein export from nucleus
GO:0051897; positive regulation of protein kinase B signaling
GO:0055114; oxidation-reduction process
GO:0098869; cellular oxidant detoxification
GO:1903206; negative regulation of hydrogen peroxide-induced cell death

Cellular component:

GO:0005634; nucleus
GO:0005654; nucleoplasm
GO:0005737; cytoplasm
GO:0005739; mitochondrion
GO:0005829; cytosol
GO:0070062; extracellular exosome

Function:

GO:0004791; thioredoxin-disulfide reductase activity
GO:0005515; protein binding
GO:0015035; protein disulfide oxidoreductase activity
GO:0015037; peptide disulfide oxidoreductase activity
GO:0016671; oxidoreductase activity, acting on a sulfur group of donors, disulfide as acceptor
GO:0044822; poly(A) RNA binding
GO:0047134; protein-disulfide reductase activity

Hide GO terms

Protein interactions and network

Protein-protein interacting partners in GenAge: TP53, MYC, EGFR, PTEN, NR3C1, NFKB1, EEF2, SOD1, PRDX1, GPX1, MAP3K5, APEX1, RAE1, MLH1, CDKN1A
STRING interaction network

Retrieve sequences for TXN

Promoter: Promoter
ORF: ORF
CDS: CDS

Homologs in model organisms

Danio rerio: zgc:56493
Drosophila melanogaster: TrxT
Mus musculus: Txn
Rattus norvegicus: Txn
Saccharomyces cerevisiae: TRX1
Schizosaccharomyces pombe: trx1

In other databases

GenAge model organism genes

A homolog of this gene for Drosophila melanogaster is present as TrxT
A homolog of this gene for Mus musculus is present as Txn1
A homolog of this gene for Saccharomyces cerevisiae is present as TRX1

CellAge

This gene is present as TXN