GenAge entry for BAK1 (Homo sapiens)
Gene name (HAGRID: 278)
- HGNC symbol
- BAK1
- Aliases
- BCL2L7; BAK; CDN1
- Common name
- BCL2-antagonist/killer 1
Potential relevance to the human ageing process
- Main reason for selection
- Entry selected based on evidence linking the gene product to a pathway or mechanism linked to ageing
- Description
The BCL2 oncogene is a potent suppressor of apoptosis under diverse conditions. BAK1, a gene belonging to the BCL2 family, promotes cell death and counteracts the protection from apoptosis provided by BCL2 [2198]. Bak knockout mice showed reduced age-related apoptotic cell death of spiral ganglion neurons and hair cells in the cochlea, which in turn resulted in the prevention of age-related hearing loss [2200].
Cytogenetic information
- Cytogenetic band
- 6p21.3
- Location
- 33,572,546 bp to 33,580,293 bp
- Orientation
- Minus strand
Protein information
- Gene Ontology
-
Process: GO:0001782; B cell homeostasis
GO:0001783; B cell apoptotic process
GO:0001836; release of cytochrome c from mitochondria
GO:0001974; blood vessel remodeling
GO:0002262; myeloid cell homeostasis
GO:0002352; B cell negative selection
GO:0006987; activation of signaling protein activity involved in unfolded protein response
GO:0007420; brain development
GO:0007568; aging
GO:0008053; mitochondrial fusion
GO:0008283; cell proliferation
And 44 more GO terms Cellular component: GO:0005739; mitochondrion
GO:0005741; mitochondrial outer membrane
GO:0005783; endoplasmic reticulum
GO:0005829; cytosol
GO:0031307; integral component of mitochondrial outer membrane
GO:0046930; pore complex
Show all GO termsFunction: GO:0005515; protein binding
GO:0031072; heat shock protein binding
GO:0042802; identical protein binding
GO:0042803; protein homodimerization activity
GO:0044325; ion channel binding
GO:0046872; metal ion binding
GO:0046982; protein heterodimerization activity
GO:0051087; chaperone binding
GO:0051400; BH domain binding
Protein interactions and network
- Protein-protein interacting partners in GenAge
- TP53, BCL2, BAX, HSPD1, DBN1, BAK1
- STRING interaction network
