GenAge entry for MED1 (Homo sapiens)
Gene name (HAGRID: 173)
- HGNC symbol
- MED1
- Aliases
- PBP; TRAP220; RB18A; DRIP230; CRSP200; CRSP1; TRIP2; PPARGBP; PPARBP
- Common name
- mediator complex subunit 1
Potential relevance to the human ageing process
- Main reason for selection
- Entry selected based on indirect or inconclusive evidence linking the gene product to ageing in humans or in one or more model systems
- Description
MED1 is a transcriptional coactivator involved in embryonic development and important for SP1 activity [785]. MED1-null mice die at embryonic stages [785]. Certain age-related pathologies, such as heart disease, may be related to PPARs [392], but it unclear whether MED1 is a major player in human ageing.
Cytogenetic information
- Cytogenetic band
- 17q12
- Location
- 39,404,285 bp to 39,451,274 bp
- Orientation
- Minus strand
Protein information
- Gene Ontology
-
Process: GO:0000122; negative regulation of transcription from RNA polymerase II promoter
GO:0000902; cell morphogenesis
GO:0001525; angiogenesis
GO:0001889; liver development
GO:0001892; embryonic placenta development
GO:0002088; lens development in camera-type eye
GO:0002154; thyroid hormone mediated signaling pathway
GO:0003222; ventricular trabecula myocardium morphogenesis
GO:0003406; retinal pigment epithelium development
GO:0006356; regulation of transcription from RNA polymerase I promoter
GO:0006367; transcription initiation from RNA polymerase II promoter
And 47 more GO terms Cellular component: GO:0000151; ubiquitin ligase complex
GO:0000785; chromatin
GO:0005634; nucleus
GO:0005654; nucleoplasm
GO:0005730; nucleolus
GO:0016020; membrane
GO:0016592; mediator complex
GO:0032993; protein-DNA complex
Show all GO termsFunction: GO:0000978; RNA polymerase II core promoter proximal region sequence-specific DNA binding
GO:0000981; RNA polymerase II transcription factor activity, sequence-specific DNA binding
GO:0001047; core promoter binding
GO:0001104; RNA polymerase II transcription cofactor activity
GO:0003682; chromatin binding
GO:0003712; transcription cofactor activity
GO:0003713; transcription coactivator activity
GO:0004872; receptor activity
GO:0005515; protein binding
GO:0008134; transcription factor binding
GO:0016922; ligand-dependent nuclear receptor binding
And 13 more GO terms
Protein interactions and network
- Protein-protein interacting partners in GenAge
- POU1F1, TP53, ATM, MYC, PARP1, PIN1, NR3C1, AR, MED1, MDM2, ESR1, PPARGC1A, PPARG
- STRING interaction network
