GenAge entry for PPARGC1A (Homo sapiens)
Entry selected based on evidence directly linking the gene product to ageing in a mammalian model organism
Gene name (HAGRID: 256)
- HGNC symbol
- PPARGC1A
- Aliases
- PGC1; PGC1A; PPARGC1
- Common name
- peroxisome proliferator-activated receptor gamma, coactivator 1 alpha
Potential relevance to the human ageing process
- Main reason for selection
- Entry selected based on evidence directly linking the gene product to ageing in a mammalian model organism
- Description
PPARGC1A is a transcriptional coactivator that regulates and interacts with genes involved in energy metabolism [1847]. It has a role in regulating metabolism, inflammation, oxidative stress resistance and mitochondrial biogenesis and function [4340]. SIRT1 has been reported to be a functional regulator of PPARGC1A [1846].
In mice, knockout of PPARGC1A accelerates vascular aging and atherosclerosis, coinciding with telomere dysfunction and shortening and DNA damage. Expression of PPARGC1A coactivates TERT transcription and reverses telomere malfunction [4340]. In humans, PPARGC1A has been associated with cholesterol and obesity as well as age-related diseases like type 2 diabetes. Thus, PPARGC1A may play a role in in ameliorating senescence, aging, and age-associated chronic diseases.
Cytogenetic information
- Cytogenetic band
- 4p15.1
- Location
- 23,792,021 bp to 23,890,077 bp
- Orientation
- Minus strand
Protein information
- Gene Ontology
-
Process: GO:0000302; response to reactive oxygen species
GO:0000422; mitophagy
GO:0001659; temperature homeostasis
GO:0001678; cellular glucose homeostasis
GO:0001933; negative regulation of protein phosphorylation
GO:0002021; response to dietary excess
GO:0002931; response to ischemia
GO:0006012; galactose metabolic process
GO:0006094; gluconeogenesis
GO:0006355; regulation of transcription, DNA-templated
GO:0006367; transcription initiation from RNA polymerase II promoter
And 72 more GO terms Cellular component: GO:0005634; nucleus
GO:0005654; nucleoplasm
GO:0005665; DNA-directed RNA polymerase II, core complex
GO:0005719; nuclear euchromatin
GO:0016605; PML body
GO:0022626; cytosolic ribosome
GO:0043025; neuronal cell body
GO:0097440; apical dendrite
GO:1990843; subsarcolemmal mitochondrion
GO:1990844; interfibrillar mitochondrion
Show all GO termsFunction: GO:0000166; nucleotide binding
GO:0001104; RNA polymerase II transcription cofactor activity
GO:0003677; DNA binding
GO:0003713; transcription coactivator activity
GO:0003723; RNA binding
GO:0005515; protein binding
GO:0008134; transcription factor binding
GO:0016922; ligand-dependent nuclear receptor binding
GO:0030331; estrogen receptor binding
GO:0030374; ligand-dependent nuclear receptor transcription coactivator activity
GO:0031490; chromatin DNA binding
And 7 more GO terms
Protein interactions and network
- Protein-protein interacting partners in GenAge
- TP53, EGFR, PPARA, CREBBP, NR3C1, NFKB1, UBE2I, EP300, PML, GSK3B, RELA, SIRT1, MED1, ESR1, PPARG
- STRING interaction network
