GenAge entry for UCHL1 (Homo sapiens)

Gene name (HAGRID: 136)

HGNC symbol: UCHL1
Aliases: PGP9.5; Uch-L1; PARK5
Common name: ubiquitin carboxyl-terminal esterase L1 (ubiquitin thiolesterase)

Potential relevance to the human ageing process

Main reason for selection: Entry selected based on indirect or inconclusive evidence linking the gene product to ageing in humans or in one or more model systems
Description: UCHL1 has both ligase and hydrolase activities [689], and it may be involved in protein degradation. Results from lower life forms implicate similar stress-response proteins in ageing. In humans, there is evidence linking UCHL1 mutations to Parkinson's disease [687]. Brain ageing and neurodegenerative diseases in humans have also been associated with the progressive accumulation of ubiquitinated protein conjugates, which are pathologically similar to the degeneration found in mice with disrupted UCHL1 [1696]. Nonetheless, it is unclear whether UCHL1 is related to human ageing.

Cytogenetic information

Cytogenetic band: 4p14
Location: 41,256,881 bp to 41,268,429 bp
Orientation: Plus strand

Display region using the UCSC Genome Browser (GRCh38/hg38)

Protein information

Gene Ontology

Process:

GO:0002931; response to ischemia
GO:0007412; axon target recognition
GO:0007628; adult walking behavior
GO:0008283; cell proliferation
GO:0016241; regulation of macroautophagy
GO:0016579; protein deubiquitination
GO:0019233; sensory perception of pain
GO:0019896; axonal transport of mitochondrion
GO:0042755; eating behavior
GO:0043161; proteasome-mediated ubiquitin-dependent protein catabolic process
GO:0043407; negative regulation of MAP kinase activity

And 3 more GO terms

Cellular component:

GO:0005654; nucleoplasm
GO:0005737; cytoplasm
GO:0005789; endoplasmic reticulum membrane
GO:0005829; cytosol
GO:0005886; plasma membrane
GO:0043025; neuronal cell body
GO:0043209; myelin sheath
GO:0044306; neuron projection terminus
GO:0070062; extracellular exosome
GO:1904115; axon cytoplasm

Function:

GO:0004197; cysteine-type endopeptidase activity
GO:0004843; thiol-dependent ubiquitin-specific protease activity
GO:0005515; protein binding
GO:0008242; omega peptidase activity
GO:0016874; ligase activity
GO:0031625; ubiquitin protein ligase binding
GO:0031694; alpha-2A adrenergic receptor binding
GO:0043130; ubiquitin binding

Show all GO terms

Protein interactions and network

Protein-protein interacting partners in GenAge: TP53, AKT1, EGFR, HSP90AA1, UBE2I, APP, HSPA8, CDK1, MDM2, CTNNB1, CDKN2A
STRING interaction network

Retrieve sequences for UCHL1

Promoter: Promoter
ORF: ORF
CDS: CDS

Homologs in model organisms

Caenorhabditis elegans: ubh-2
Danio rerio: uchl1
Drosophila melanogaster: Uch
Mus musculus: Uchl1
Rattus norvegicus: Uchl1
Saccharomyces cerevisiae: YUH1
Schizosaccharomyces pombe: uch1

In other databases

GenAge model organism genes

A homolog of this gene for Saccharomyces cerevisiae is present as YUH1

CellAge gene expression

This gene is present as UCHL1