GenAge entry for CDK1 (Homo sapiens)

Gene name (HAGRID: 201)

HGNC symbol: CDK1
Aliases: CDC28A; CDC2
Common name: cyclin-dependent kinase 1

Potential relevance to the human ageing process

Main reason for selection: Entry selected based on evidence showing that the gene product to be a target of genes previously linked to ageing
Description: An important regulator of the cell cycle, CDK1 also appears to be involved in apoptosis. Age-related alterations to CDK1 have been reported in rats [875], but there is no direct evidence linking CDK1 to human ageing.

Cytogenetic information

Cytogenetic band: 10q21.1
Location: 60,778,454 bp to 60,794,852 bp
Orientation: Plus strand

Display region using the UCSC Genome Browser (GRCh38/hg38)

Protein information

Gene Ontology

Process:

GO:0000082; G1/S transition of mitotic cell cycle
GO:0000083; regulation of transcription involved in G1/S transition of mitotic cell cycle
GO:0000086; G2/M transition of mitotic cell cycle
GO:0000187; activation of MAPK activity
GO:0000226; microtubule cytoskeleton organization
GO:0006260; DNA replication
GO:0006281; DNA repair
GO:0006461; protein complex assembly
GO:0006915; apoptotic process
GO:0006977; DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest
GO:0007067; mitotic nuclear division

And 43 more GO terms

Cellular component:	GO:0000784; nuclear chromosome, telomeric region GO:0005634; nucleus GO:0005654; nucleoplasm GO:0005737; cytoplasm GO:0005739; mitochondrion GO:0005813; centrosome GO:0005829; cytosol GO:0005876; spindle microtubule GO:0016020; membrane GO:0030496; midbody GO:0070062; extracellular exosome
	And 2 more GO terms

Function:

GO:0003682; chromatin binding
GO:0004672; protein kinase activity
GO:0004674; protein serine/threonine kinase activity
GO:0004693; cyclin-dependent protein serine/threonine kinase activity
GO:0005515; protein binding
GO:0005524; ATP binding
GO:0008353; RNA polymerase II carboxy-terminal domain kinase activity
GO:0030332; cyclin binding
GO:0030544; Hsp70 protein binding
GO:0035173; histone kinase activity

Show all GO terms

Protein interactions and network

Protein-protein interacting partners in GenAge: TP53, E2F1, EGFR, BRCA1, RPA1, BCL2, VCP, HSP90AA1, ABL1, UBE2I, EP300, PML, FEN1, RB1, FOXM1, UCHL1, SIRT1, SP1, HMGB1, CCNA2, LMNB1, CDK1, TFDP1, POLA1, PPP1CA, TP53BP1, CDKN1A, HTRA2, SQSTM1, CDK7
STRING interaction network

Retrieve sequences for CDK1

Promoter: Promoter
ORF: ORF
CDS: CDS

Homologs in model organisms

Caenorhabditis elegans: cdk-1
Danio rerio: cdk1
Drosophila melanogaster: cdc2
Mus musculus: Cdk1
Rattus norvegicus: Cdk1
Saccharomyces cerevisiae: CDC28

In other databases

CellAge

This gene is present as CDK1

CellAge gene expression

This gene is present as CDK1