GenAge entry for CCNA2 (Homo sapiens)
Gene name (HAGRID: 177)
- HGNC symbol
- CCNA2
- Aliases
- CCNA; CCN1
- Common name
- cyclin A2
Potential relevance to the human ageing process
- Main reason for selection
- Entry selected based on evidence showing that the gene product to be a target of genes previously linked to ageing
- Description
Important cyclin involved in cell cycle control [794], CCNA2 could be a downstream target of pathways related to senescence and ageing. CCNA2's role in human ageing is unknown.
Cytogenetic information
- Cytogenetic band
- 4q27
- Location
- 121,816,444 bp to 121,823,933 bp
- Orientation
- Minus strand
Protein information
- Gene Ontology
-
Process: GO:0000079; regulation of cyclin-dependent protein serine/threonine kinase activity
GO:0000086; G2/M transition of mitotic cell cycle
GO:0007067; mitotic nuclear division
GO:0007265; Ras protein signal transduction
GO:0010389; regulation of G2/M transition of mitotic cell cycle
GO:0016032; viral process
GO:0031100; animal organ regeneration
GO:0033762; response to glucagon
GO:0036120; cellular response to platelet-derived growth factor stimulus
GO:0044320; cellular response to leptin stimulus
GO:0045893; positive regulation of transcription, DNA-templated
And 11 more GO terms Cellular component: GO:0001939; female pronucleus
GO:0001940; male pronucleus
GO:0005634; nucleus
GO:0005654; nucleoplasm
GO:0005737; cytoplasm
GO:0005794; Golgi apparatus
GO:0097124; cyclin A2-CDK2 complex
Show all GO termsFunction: GO:0005515; protein binding
GO:0019901; protein kinase binding
Protein interactions and network
- Protein-protein interacting partners in GenAge
- TP53, E2F1, BRCA1, CREBBP, RPA1, BRCA2, EP300, PCNA, FEN1, RB1, SP1, CCNA2, BUB1B, CDK1, POLA1, HDAC2, CTNNB1, TP73, CDKN1A, CDK7
- STRING interaction network
