GenAge entry for PRDX1 (Homo sapiens)

Gene name (HAGRID: 141)

HGNC symbol: PRDX1
Aliases: NKEFA; PAGA
Common name: peroxiredoxin 1

Potential relevance to the human ageing process

Main reason for selection: Entry selected based on evidence linking the gene product to a pathway or mechanism linked to ageing
Description: PRDX1 is involved in redox regulation and possibly in intracellular signalling cascades. Mice lacking PRDX1 have a shorter longevity due to anaemia and cancer, though it is unclear whether these animals age faster [50]. PRDX1 has not been directly associated with human ageing.

Cytogenetic information

Cytogenetic band: 1p34.1
Location: 45,511,035 bp to 45,521,938 bp
Orientation: Minus strand

Display region using the UCSC Genome Browser (GRCh38/hg38)

Protein information

Gene Ontology

Process:

GO:0000302; response to reactive oxygen species
GO:0001501; skeletal system development
GO:0001895; retina homeostasis
GO:0008283; cell proliferation
GO:0019430; removal of superoxide radicals
GO:0032872; regulation of stress-activated MAPK cascade
GO:0034101; erythrocyte homeostasis
GO:0042267; natural killer cell mediated cytotoxicity
GO:0042345; regulation of NF-kappaB import into nucleus
GO:0042744; hydrogen peroxide catabolic process
GO:0045454; cell redox homeostasis

And 3 more GO terms

Cellular component:

GO:0005615; extracellular space
GO:0005634; nucleus
GO:0005737; cytoplasm
GO:0005739; mitochondrion
GO:0005829; cytosol
GO:0005913; cell-cell adherens junction
GO:0031012; extracellular matrix
GO:0042470; melanosome
GO:0043209; myelin sheath
GO:0070062; extracellular exosome

Function:

GO:0004601; peroxidase activity
GO:0005515; protein binding
GO:0008379; thioredoxin peroxidase activity
GO:0042802; identical protein binding
GO:0044822; poly(A) RNA binding
GO:0098641; cadherin binding involved in cell-cell adhesion

Show all GO terms

Protein interactions and network

Protein-protein interacting partners in GenAge: SHC1, TXN, MYC, EGFR, PTEN, RPA1, ABL1, TERF1, PRKDC, CAT, BAX, SOD1, PRDX1, RAD52, CDC42
STRING interaction network

Retrieve sequences for PRDX1

ORF: ORF
CDS: CDS

Homologs in model organisms

Caenorhabditis elegans: prdx-2
Danio rerio: prdx1
Drosophila melanogaster: Jafrac1
Mus musculus: Prdx1
Rattus norvegicus: Prdx1

In other databases

GenAge model organism genes

A homolog of this gene for Caenorhabditis elegans is present as prdx-2
A homolog of this gene for Mus musculus is present as Prdx1
A homolog of this gene for Drosophila melanogaster is present as Jafrac1