GenAge entry for RAD51 (Homo sapiens)

Gene name (HAGRID: 84)

HGNC symbol: RAD51
Aliases: HsRad51; HsT16930; BRCC5; FANCR; RAD51A; RECA
Common name: RAD51 recombinase

Potential relevance to the human ageing process

Main reason for selection: Entry selected based on evidence directly linking the gene product to ageing in a cellular model system
Description: Involved in DNA unwinding and repair [489], RAD51 has been reported to be an important player in the cellular senescence of yeast [192]. Disruption of RAD51 in mice results in embryonic lethality [488]. Its role in mammalian ageing remains unknown.

Cytogenetic information

Cytogenetic band: 15q15.1
Location: 40,695,129 bp to 40,732,158 bp
Orientation: Plus strand

Display region using the UCSC Genome Browser (GRCh38/hg38)

Protein information

Gene Ontology

Process:

GO:0000722; telomere maintenance via recombination
GO:0000724; double-strand break repair via homologous recombination
GO:0000730; DNA recombinase assembly
GO:0000731; DNA synthesis involved in DNA repair
GO:0000732; strand displacement
GO:0001932; regulation of protein phosphorylation
GO:0006268; DNA unwinding involved in DNA replication
GO:0006281; DNA repair
GO:0006310; DNA recombination
GO:0006312; mitotic recombination
GO:0006974; cellular response to DNA damage stimulus

And 22 more GO terms

Cellular component:	GO:0000228; nuclear chromosome GO:0000784; nuclear chromosome, telomeric region GO:0000785; chromatin GO:0000790; nuclear chromatin GO:0000793; condensed chromosome GO:0000794; condensed nuclear chromosome GO:0000800; lateral element GO:0005634; nucleus GO:0005654; nucleoplasm GO:0005730; nucleolus GO:0005737; cytoplasm
	And 7 more GO terms

Function:

GO:0000150; recombinase activity
GO:0000400; four-way junction DNA binding
GO:0003682; chromatin binding
GO:0003690; double-stranded DNA binding
GO:0003697; single-stranded DNA binding
GO:0004520; endodeoxyribonuclease activity
GO:0005515; protein binding
GO:0005524; ATP binding
GO:0008022; protein C-terminus binding
GO:0042802; identical protein binding
GO:0043142; single-stranded DNA-dependent ATPase activity

And 2 more GO terms

Show all GO terms

Protein interactions and network

Protein-protein interacting partners in GenAge: TP53, ATM, WRN, BRCA1, RPA1, BLM, HSP90AA1, ABL1, BRCA2, RAD51, UBE2I, PML, PCNA, RAD52, SP1, SUMO1, H2AFX, ESR1, CDC42
STRING interaction network

Retrieve sequences for RAD51

Promoter: Promoter
ORF: ORF
CDS: CDS

Homologs in model organisms

Caenorhabditis elegans: rad-51
Danio rerio: rad51
Drosophila melanogaster: spn-A
Mus musculus: Rad51
Rattus norvegicus: LOC100911267
Saccharomyces cerevisiae: RAD51
Schizosaccharomyces pombe: rhp51

In other databases

GenAge model organism genes

A homolog of this gene for Saccharomyces cerevisiae is present as RAD51

LongevityMap

This gene is present as RAD51

CellAge gene expression

This gene is present as RAD51