GenAge entry for H2AFX (Homo sapiens)

Gene name (HAGRID: 212)

HGNC symbol: H2AFX
Aliases: H2AX
Common name: H2A histone family, member X

Potential relevance to the human ageing process

Main reason for selection: Entry selected based on evidence linking the gene product to a pathway or mechanism linked to ageing
Description: Histones such as H2AFX are part of the nucleosome, which consists of DNA wrapped around histones. H2AFX has been involved in DNA repair together with, among others, NBN and TP53 [1004]. H2AFX-null mice were growth retarded and showed signs of genomic instability [1004]. Whether H2AFX plays a role in human ageing remains to be determined.

Cytogenetic information

Cytogenetic band: 11q23.3
Location: 119,093,875 bp to 119,095,467 bp
Orientation: Minus strand

Display region using the UCSC Genome Browser (GRCh38/hg38)

Protein information

Gene Ontology

Process:

GO:0000077; DNA damage checkpoint
GO:0000724; double-strand break repair via homologous recombination
GO:0006302; double-strand break repair
GO:0006303; double-strand break repair via nonhomologous end joining
GO:0006334; nucleosome assembly
GO:0006342; chromatin silencing
GO:0006974; cellular response to DNA damage stimulus
GO:0007283; spermatogenesis
GO:0010212; response to ionizing radiation
GO:0016032; viral process
GO:0021987; cerebral cortex development

And 5 more GO terms

Cellular component:	GO:0000781; chromosome, telomeric region GO:0000786; nucleosome GO:0000790; nuclear chromatin GO:0000794; condensed nuclear chromosome GO:0001673; male germ cell nucleus GO:0001741; XY body GO:0005634; nucleus GO:0005654; nucleoplasm GO:0005657; replication fork GO:0035861; site of double-strand break GO:0070062; extracellular exosome
	And 1 more GO terms

Function:

GO:0003677; DNA binding
GO:0003684; damaged DNA binding
GO:0005515; protein binding
GO:0019899; enzyme binding
GO:0042393; histone binding
GO:0046982; protein heterodimerization activity

Show all GO terms

Protein interactions and network

Protein-protein interacting partners in GenAge: TP53, ATM, WRN, LMNA, NGFR, EGFR, NBN, PARP1, BRCA1, BLM, HSP90AA1, BRCA2, RAD51, STK11, PML, PRKDC, XRCC5, TERF2, XRCC6, FOXO3, SOD2, AIFM1, A2M, HSPA9, HSPA1A, MAPK8, YWHAZ, BMI1, EEF1A1, ATF2, ESR1, CLU, ATR, PPM1D, PAPPA, SIRT7, TP53BP1, TRAP1
STRING interaction network

Retrieve sequences for H2AFX

ORF: ORF
CDS: CDS

Homologs in model organisms

Caenorhabditis elegans: his-35
Danio rerio: h2afx
Drosophila melanogaster: His2A:CG33856
Mus musculus: H2afx
Rattus norvegicus: H2afx

In other databases

LongevityMap

This gene is present as H2AFX

CellAge gene expression

This gene is present as H2AFX