GenAge entry for VCP (Homo sapiens)

Gene name (HAGRID: 71)

HGNC symbol: VCP
Aliases: IBMPFD; p97
Common name: valosin containing protein

Potential relevance to the human ageing process

Main reason for selection: Entry selected based on evidence showing that the gene product to be a target of genes previously linked to ageing
Description: Also known as p97, VCP is required for the export of endoplasmic reticulum proteins into the cytosol [455]. Its interaction with WRN and a possible role in WRN's DNA damage response pathway makes it an intriguing protein [454], even though it has not been directly linked to ageing.

Cytogenetic information

Cytogenetic band: 9p13.3
Location: 35,056,068 bp to 35,072,742 bp
Orientation: Minus strand

Display region using the UCSC Genome Browser (GRCh38/hg38)

Protein information

Gene Ontology

Process:

GO:0006281; DNA repair
GO:0006302; double-strand break repair
GO:0006734; NADH metabolic process
GO:0006888; ER to Golgi vesicle-mediated transport
GO:0006914; autophagy
GO:0006919; activation of cysteine-type endopeptidase activity involved in apoptotic process
GO:0006974; cellular response to DNA damage stimulus
GO:0010918; positive regulation of mitochondrial membrane potential
GO:0016567; protein ubiquitination
GO:0018279; protein N-linked glycosylation via asparagine
GO:0019079; viral genome replication

And 26 more GO terms

Cellular component:	GO:0000502; proteasome complex GO:0005634; nucleus GO:0005654; nucleoplasm GO:0005737; cytoplasm GO:0005783; endoplasmic reticulum GO:0005789; endoplasmic reticulum membrane GO:0005811; lipid particle GO:0005829; cytosol GO:0034098; VCP-NPL4-UFD1 AAA ATPase complex GO:0035861; site of double-strand break GO:0036513; Derlin-1 retrotranslocation complex
	And 6 more GO terms

Function:	GO:0005515; protein binding GO:0005524; ATP binding GO:0008289; lipid binding GO:0016887; ATPase activity GO:0019903; protein phosphatase binding GO:0019904; protein domain specific binding GO:0031593; polyubiquitin binding GO:0031625; ubiquitin protein ligase binding GO:0035800; deubiquitinase activator activity GO:0036435; K48-linked polyubiquitin binding GO:0042288; MHC class I protein binding
	And 7 more GO terms

Show all GO terms

Protein interactions and network

Protein-protein interacting partners in GenAge: TP53, ERCC8, WRN, LMNA, NFKB2, AKT1, PRKCD, BRCA1, HIF1A, UBB, BLM, VCP, HSP90AA1, NFKB1, TOP1, ERCC6, HTT, HELLS, AR, TERF2, BAX, GRB2, HSPD1, HSPA1A, YWHAZ, MAPK3, PTGS2, HSPA8, CDK1, MDM2, SUMO1, ESR1, NFKBIA, MTOR, TP63, STUB1, CHEK2, SIRT7, TP53BP1, CDKN1A, HTRA2, SPRTN
STRING interaction network

Retrieve sequences for VCP

Promoter: Promoter
ORF: ORF
CDS: CDS

Homologs in model organisms

Caenorhabditis elegans: cdc-48.1
Danio rerio: vcp
Drosophila melanogaster: TER94
Mus musculus: Vcp
Rattus norvegicus: Vcp
Saccharomyces cerevisiae: CDC48
Schizosaccharomyces pombe: cdc48

In other databases

GenAge model organism genes

A homolog of this gene for Caenorhabditis elegans is present as cdc-48.1