GenAge entry for AIFM1 (Homo sapiens)

Gene name (HAGRID: 135)

HGNC symbol: AIFM1
Aliases: AIF; CMTX4; PDCD8; NAMSD
Common name: apoptosis-inducing factor, mitochondrion-associated, 1

Potential relevance to the human ageing process

Main reason for selection: Entry selected based on evidence linking the gene product to a pathway or mechanism linked to ageing
Description: AIFM1 is an important player in apoptosis that has been related to tumorigenesis [686]. It also appears to regulate PARP1-dependent apoptosis [415]. AIFM1 has not been directly linked to ageing.

Cytogenetic information

Cytogenetic band: Xq26.1
Location: 130,129,363 bp to 130,165,887 bp
Orientation: Minus strand

Display region using the UCSC Genome Browser (GRCh38/hg38)

Protein information

Gene Ontology

Process:

GO:0002931; response to ischemia
GO:0006915; apoptotic process
GO:0006919; activation of cysteine-type endopeptidase activity involved in apoptotic process
GO:0009636; response to toxic substance
GO:0030261; chromosome condensation
GO:0043065; positive regulation of apoptotic process
GO:0043525; positive regulation of neuron apoptotic process
GO:0045454; cell redox homeostasis
GO:0051402; neuron apoptotic process
GO:0055114; oxidation-reduction process
GO:0070059; intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress
GO:0070301; cellular response to hydrogen peroxide
GO:0071392; cellular response to estradiol stimulus
GO:0071732; cellular response to nitric oxide
GO:0090650; cellular response to oxygen-glucose deprivation
GO:1902065; response to L-glutamate
GO:1902510; regulation of apoptotic DNA fragmentation
GO:1904045; cellular response to aldosterone

Cellular component:

GO:0005634; nucleus
GO:0005739; mitochondrion
GO:0005743; mitochondrial inner membrane
GO:0005758; mitochondrial intermembrane space
GO:0005829; cytosol
GO:0048471; perinuclear region of cytoplasm

Function:

GO:0003677; DNA binding
GO:0005515; protein binding
GO:0016174; NAD(P)H oxidase activity
GO:0016651; oxidoreductase activity, acting on NAD(P)H
GO:0046983; protein dimerization activity
GO:0071949; FAD binding

Hide GO terms

Protein interactions and network

Protein-protein interacting partners in GenAge: SHC1, EGFR, GSR, HSPA1A, BMI1, H2AFX, ESR1, MLH1
STRING interaction network

Retrieve sequences for AIFM1

ORF: ORF
CDS: CDS

Homologs in model organisms

Caenorhabditis elegans: wah-1
Danio rerio: pdcd8
Drosophila melanogaster: AIF
Mus musculus: Aifm1
Rattus norvegicus: Aifm1

In other databases

GenAge model organism genes

A homolog of this gene for Caenorhabditis elegans is present as wah-1