GenAge entry for CCNA2 (Homo sapiens)

Gene name (HAGRID: 177)

HGNC symbol: CCNA2
Aliases: CCNA; CCN1
Common name: cyclin A2

Potential relevance to the human ageing process

Main reason for selection: Entry selected based on evidence showing that the gene product to be a target of genes previously linked to ageing
Description: Important cyclin involved in cell cycle control [794], CCNA2 could be a downstream target of pathways related to senescence and ageing. CCNA2's role in human ageing is unknown.

Cytogenetic information

Cytogenetic band: 4q27
Location: 121,816,444 bp to 121,823,933 bp
Orientation: Minus strand

Display region using the UCSC Genome Browser (GRCh38/hg38)

Protein information

Gene Ontology

Process:

GO:0000079; regulation of cyclin-dependent protein serine/threonine kinase activity
GO:0000086; G2/M transition of mitotic cell cycle
GO:0007067; mitotic nuclear division
GO:0007265; Ras protein signal transduction
GO:0010389; regulation of G2/M transition of mitotic cell cycle
GO:0016032; viral process
GO:0031100; animal organ regeneration
GO:0033762; response to glucagon
GO:0036120; cellular response to platelet-derived growth factor stimulus
GO:0044320; cellular response to leptin stimulus
GO:0045893; positive regulation of transcription, DNA-templated
GO:0048146; positive regulation of fibroblast proliferation
GO:0051301; cell division
GO:0071314; cellular response to cocaine
GO:0071373; cellular response to luteinizing hormone stimulus
GO:0071392; cellular response to estradiol stimulus
GO:0071456; cellular response to hypoxia
GO:0071732; cellular response to nitric oxide
GO:0090102; cochlea development
GO:1903463; regulation of mitotic cell cycle DNA replication
GO:1990314; cellular response to insulin-like growth factor stimulus

Cellular component:

GO:0001939; female pronucleus
GO:0001940; male pronucleus
GO:0005634; nucleus
GO:0005654; nucleoplasm
GO:0005737; cytoplasm
GO:0005794; Golgi apparatus
GO:0097124; cyclin A2-CDK2 complex

Function:

GO:0005515; protein binding
GO:0019901; protein kinase binding

Hide GO terms

Protein interactions and network

Protein-protein interacting partners in GenAge: TP53, E2F1, BRCA1, CREBBP, RPA1, BRCA2, EP300, PCNA, FEN1, RB1, SP1, CCNA2, BUB1B, CDK1, POLA1, HDAC2, CTNNB1, TP73, CDKN1A, CDK7
STRING interaction network

Retrieve sequences for CCNA2

ORF: ORF
CDS: CDS

Homologs in model organisms

Caenorhabditis elegans: ZK507.6
Drosophila melanogaster: CycA
Mus musculus: Ccna2
Rattus norvegicus: Ccna2

In other databases

CellAge

This gene is present as CCNA2

CellAge gene expression

This gene is present as CCNA2