GenAge entry for EEF2 (Homo sapiens)

Gene name (HAGRID: 103)

HGNC symbol: EEF2
Aliases: EEF-2; EF2
Common name: eukaryotic translation elongation factor 2

Potential relevance to the human ageing process

Main reason for selection: Entry selected based on indirect or inconclusive evidence linking the gene product to ageing in humans or in one or more model systems
Description: EEF2 is involved in protein synthesis. Age-dependent changes to EEF2 in rats have been reported, which could account for the decline in protein synthesis in old animals [540]. EEF2 has not been directly related to human ageing.

Cytogenetic information

Cytogenetic band: 19p13.3
Location: 3,976,056 bp to 3,985,463 bp
Orientation: Minus strand

Display region using the UCSC Genome Browser (GRCh38/hg38)

Protein information

Gene Ontology

Process:

GO:0002244; hematopoietic progenitor cell differentiation
GO:0002931; response to ischemia
GO:0003009; skeletal muscle contraction
GO:0006414; translational elongation
GO:0007568; aging
GO:0014009; glial cell proliferation
GO:0017183; peptidyl-diphthamide biosynthetic process from peptidyl-histidine
GO:0032355; response to estradiol
GO:0034976; response to endoplasmic reticulum stress
GO:0035914; skeletal muscle cell differentiation
GO:0042493; response to drug
GO:0042542; response to hydrogen peroxide
GO:0045471; response to ethanol
GO:0045727; positive regulation of translation
GO:0051593; response to folic acid
GO:0098609; cell-cell adhesion
GO:1990416; cellular response to brain-derived neurotrophic factor stimulus
GO:2000767; positive regulation of cytoplasmic translation

Cellular component:

GO:0005634; nucleus
GO:0005737; cytoplasm
GO:0005829; cytosol
GO:0005886; plasma membrane
GO:0005913; cell-cell adherens junction
GO:0016020; membrane
GO:0016235; aggresome
GO:0030529; intracellular ribonucleoprotein complex
GO:0031012; extracellular matrix
GO:0042788; polysomal ribosome
GO:0045121; membrane raft
GO:0070062; extracellular exosome

Function:

GO:0002039; p53 binding
GO:0003746; translation elongation factor activity
GO:0003924; GTPase activity
GO:0005515; protein binding
GO:0005525; GTP binding
GO:0008097; 5S rRNA binding
GO:0019901; protein kinase binding
GO:0043022; ribosome binding
GO:0044822; poly(A) RNA binding
GO:0051015; actin filament binding
GO:0098641; cadherin binding involved in cell-cell adhesion

Hide GO terms

Protein interactions and network

Protein-protein interacting partners in GenAge: TP53, TXN, PTEN, HSP90AA1, EP300, XRCC6, GSR, HSPD1, MAPK14, EEF1A1, ATF2, BUB1B, HSPA8, MDM2, ESR1, CDKN2A, SIRT6, MLH1
STRING interaction network

Retrieve sequences for EEF2

ORF: ORF
CDS: CDS

Homologs in model organisms

Caenorhabditis elegans: eef-2
Danio rerio: eef2b
Drosophila melanogaster: Ef2b
Mus musculus: Eef2
Rattus norvegicus: Eef2
Saccharomyces cerevisiae: EFT1
Schizosaccharomyces pombe: eft201

In other databases

GenAge model organism genes

A homolog of this gene for Caenorhabditis elegans is present as eef-2
A homolog of this gene for Saccharomyces cerevisiae is present as EFT1