GenAge entry for HMGB1 (Homo sapiens)

Gene name (HAGRID: 176)

HGNC symbol: HMGB1
Aliases: HMG3; SBP-1; DKFZp686A04236; HMG1
Common name: high mobility group box 1

Potential relevance to the human ageing process

Main reason for selection: Entry selected based on evidence showing that the gene product to be a target of genes previously linked to ageing
Description: HMGB1 has been related to DNA unwinding, stress response, and maintenance of genome stability [793]. HMGB1-null mice die shortly after birth [792]. In mice, HMGB1 and other HMG chromosomal proteins have been shown to suffer alterations at various levels during ageing [790], though HMGB1 has not been directly related to human ageing.

Cytogenetic information

Cytogenetic band: 13q12
Location: 30,457,916 bp to 30,465,965 bp
Orientation: Minus strand

Display region using the UCSC Genome Browser (GRCh38/hg38)

Protein information

Gene Ontology

Process:

GO:0000122; negative regulation of transcription from RNA polymerase II promoter
GO:0001773; myeloid dendritic cell activation
GO:0002218; activation of innate immune response
GO:0002407; dendritic cell chemotaxis
GO:0002437; inflammatory response to antigenic stimulus
GO:0002643; regulation of tolerance induction
GO:0002840; regulation of T cell mediated immune response to tumor cell
GO:0006265; DNA topological change
GO:0006309; apoptotic DNA fragmentation
GO:0006310; DNA recombination
GO:0006357; regulation of transcription from RNA polymerase II promoter
GO:0006914; autophagy
GO:0006954; inflammatory response
GO:0007204; positive regulation of cytosolic calcium ion concentration
GO:0010506; regulation of autophagy
GO:0017055; negative regulation of RNA polymerase II transcriptional preinitiation complex assembly
GO:0031175; neuron projection development
GO:0032072; regulation of restriction endodeoxyribonuclease activity
GO:0032392; DNA geometric change
GO:0032425; positive regulation of mismatch repair
GO:0032689; negative regulation of interferon-gamma production
GO:0032733; positive regulation of interleukin-10 production
GO:0032735; positive regulation of interleukin-12 production
GO:0033151; V(D)J recombination
GO:0034165; positive regulation of toll-like receptor 9 signaling pathway
GO:0035711; T-helper 1 cell activation
GO:0042104; positive regulation of activated T cell proliferation
GO:0043065; positive regulation of apoptotic process
GO:0043277; apoptotic cell clearance
GO:0043280; positive regulation of cysteine-type endopeptidase activity involved in apoptotic process
GO:0043371; negative regulation of CD4-positive, alpha-beta T cell differentiation
GO:0043388; positive regulation of DNA binding
GO:0043410; positive regulation of MAPK cascade
GO:0043537; negative regulation of blood vessel endothelial cell migration
GO:0045063; T-helper 1 cell differentiation
GO:0045087; innate immune response
GO:0045944; positive regulation of transcription from RNA polymerase II promoter
GO:0046330; positive regulation of JNK cascade
GO:0050716; positive regulation of interleukin-1 secretion
GO:0050918; positive chemotaxis
GO:0051103; DNA ligation involved in DNA repair
GO:0051106; positive regulation of DNA ligation
GO:0070374; positive regulation of ERK1 and ERK2 cascade
GO:0090026; positive regulation of monocyte chemotaxis
GO:0097350; neutrophil clearance
GO:1990774; tumor necrosis factor secretion
GO:2000778; positive regulation of interleukin-6 secretion
GO:2001200; positive regulation of dendritic cell differentiation

Cellular component:

GO:0000793; condensed chromosome
GO:0005576; extracellular region
GO:0005615; extracellular space
GO:0005634; nucleus
GO:0005654; nucleoplasm
GO:0005768; endosome
GO:0005793; endoplasmic reticulum-Golgi intermediate compartment
GO:0005886; plasma membrane
GO:0009986; cell surface
GO:0017053; transcriptional repressor complex

Function:

GO:0000400; four-way junction DNA binding
GO:0000405; bubble DNA binding
GO:0001530; lipopolysaccharide binding
GO:0001786; phosphatidylserine binding
GO:0003684; damaged DNA binding
GO:0003690; double-stranded DNA binding
GO:0003697; single-stranded DNA binding
GO:0003700; transcription factor activity, sequence-specific DNA binding
GO:0005125; cytokine activity
GO:0005515; protein binding
GO:0008134; transcription factor binding
GO:0008301; DNA binding, bending
GO:0016829; lyase activity
GO:0019958; C-X-C chemokine binding
GO:0042056; chemoattractant activity
GO:0044822; poly(A) RNA binding
GO:0050786; RAGE receptor binding
GO:0070182; DNA polymerase binding
GO:0070491; repressing transcription factor binding
GO:0097100; supercoiled DNA binding

Hide GO terms

Protein interactions and network

Protein-protein interacting partners in GenAge: TP53, CREBBP, NR3C1, NFKB1, AR, TERF2, RB1, XPA, RELA, HMGB2, TBP, HSPA8, CDK1, PSEN1, TP73
STRING interaction network

Retrieve sequences for HMGB1

ORF: ORF
CDS: CDS

Homologs in model organisms

Mus musculus: Hmgb1
Rattus norvegicus: LOC685520

In other databases

LongevityMap

This gene is present as HMGB1

CellAge

This gene is present as HMGB1

CellAge gene expression

This gene is present as HMGB1