GenAge entry for MAP3K5 (Homo sapiens)

Gene name (HAGRID: 179)

HGNC symbol: MAP3K5
Aliases: MAPKKK5; ASK1; MEKK5
Common name: mitogen-activated protein kinase kinase kinase 5

Potential relevance to the human ageing process

Main reason for selection: Entry selected based on evidence showing that the gene product to be a target of genes previously linked to ageing
Description: MAP3K5, also called ASK1, is involved in stress response and apoptosis [999]. Disruption of MAP3K5 in mice attenuates left ventricular remodelling [1723]. It is possible that MAP3K5 is related to age-related changes in stress response witnessed in a number of animal models. MAP3K5 has not been directly linked to human ageing.

Cytogenetic information

Cytogenetic band: 6q22.33
Location: 136,557,049 bp to 136,792,518 bp
Orientation: Minus strand

Display region using the UCSC Genome Browser (GRCh38/hg38)

Protein information

Gene Ontology

Process:

GO:0000165; MAPK cascade
GO:0000186; activation of MAPKK activity
GO:0002931; response to ischemia
GO:0006468; protein phosphorylation
GO:0007254; JNK cascade
GO:0007257; activation of JUN kinase activity
GO:0008631; intrinsic apoptotic signaling pathway in response to oxidative stress
GO:0010666; positive regulation of cardiac muscle cell apoptotic process
GO:0016032; viral process
GO:0034976; response to endoplasmic reticulum stress
GO:0038066; p38MAPK cascade
GO:0042060; wound healing
GO:0043065; positive regulation of apoptotic process
GO:0043280; positive regulation of cysteine-type endopeptidase activity involved in apoptotic process
GO:0043507; positive regulation of JUN kinase activity
GO:0045087; innate immune response
GO:0045663; positive regulation of myoblast differentiation
GO:0046330; positive regulation of JNK cascade
GO:0070059; intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress
GO:0070301; cellular response to hydrogen peroxide
GO:0071356; cellular response to tumor necrosis factor
GO:0072577; endothelial cell apoptotic process
GO:0097190; apoptotic signaling pathway
GO:0097300; programmed necrotic cell death
GO:1900745; positive regulation of p38MAPK cascade
GO:1901216; positive regulation of neuron death
GO:1902170; cellular response to reactive nitrogen species
GO:1904707; positive regulation of vascular smooth muscle cell proliferation

Cellular component:

GO:0005829; cytosol
GO:0009897; external side of plasma membrane
GO:1902911; protein kinase complex
GO:1990604; IRE1-TRAF2-ASK1 complex

Function:

GO:0000287; magnesium ion binding
GO:0004672; protein kinase activity
GO:0004674; protein serine/threonine kinase activity
GO:0004709; MAP kinase kinase kinase activity
GO:0005515; protein binding
GO:0005524; ATP binding
GO:0019901; protein kinase binding
GO:0019903; protein phosphatase binding
GO:0042803; protein homodimerization activity

Hide GO terms

Protein interactions and network

Protein-protein interacting partners in GenAge: TXN, PTPN11, AKT1, CREBBP, HSP90AA1, EP300, FAS, APP, HSPA1A, YWHAZ, MAP3K5, PIK3R1, JAK2, STUB1, CDKN1A
STRING interaction network

Retrieve sequences for MAP3K5

ORF: ORF
CDS: CDS

Homologs in model organisms

Danio rerio: map3k5
Drosophila melanogaster: Pk92B
Mus musculus: Map3k5
Rattus norvegicus: Map3k5

In other databases

CellAge

This gene is present as MAP3K5