GenAge entry for NGFR (Homo sapiens)
Gene name (HAGRID: 37)
- HGNC symbol
- NGFR
- Aliases
- TNFRSF16; CD271; p75NTR
- Common name
- nerve growth factor receptor
Potential relevance to the human ageing process
- Main reason for selection
- Entry selected based on evidence showing that the gene product to be a target of genes previously linked to ageing
- Description
A receptor that can bind not only NGF but other neurotrophins, such as BDNF, NGFR mediates neural cell survival and is an important player in development. Results from mice suggest it may be related to brain ageing [337], though if and how it impacts on the human ageing process is not known.
Cytogenetic information
- Cytogenetic band
- 17q21-q22
- Location
- 49,495,293 bp to 49,515,020 bp
- Orientation
- Plus strand
Protein information
- Gene Ontology
-
Process: GO:0006886; intracellular protein transport
GO:0006919; activation of cysteine-type endopeptidase activity involved in apoptotic process
GO:0006954; inflammatory response
GO:0006955; immune response
GO:0007411; axon guidance
GO:0010977; negative regulation of neuron projection development
GO:0031293; membrane protein intracellular domain proteolysis
GO:0032496; response to lipopolysaccharide
GO:0032922; circadian regulation of gene expression
GO:0033209; tumor necrosis factor-mediated signaling pathway
GO:0042127; regulation of cell proliferation
GO:0042593; glucose homeostasis
GO:0042981; regulation of apoptotic process
GO:0043065; positive regulation of apoptotic process
GO:0043066; negative regulation of apoptotic process
GO:0043154; negative regulation of cysteine-type endopeptidase activity involved in apoptotic process
GO:0043281; regulation of cysteine-type endopeptidase activity involved in apoptotic process
GO:0043410; positive regulation of MAPK cascade
GO:0048011; neurotrophin TRK receptor signaling pathway
GO:0050771; negative regulation of axonogenesis
GO:0050772; positive regulation of axonogenesis
GO:0097190; apoptotic signaling pathway
GO:1900182; positive regulation of protein localization to nucleus
GO:1902895; positive regulation of pri-miRNA transcription from RNA polymerase II promoter
GO:1903588; negative regulation of blood vessel endothelial cell proliferation involved in sprouting angiogenesis
GO:2001273; regulation of glucose import in response to insulin stimulus
Cellular component: GO:0005576; extracellular region
GO:0005634; nucleus
GO:0005654; nucleoplasm
GO:0005768; endosome
GO:0005829; cytosol
GO:0005886; plasma membrane
GO:0005887; integral component of plasma membrane
GO:0009986; cell surface
GO:0043005; neuron projection
Hide GO termsFunction: GO:0004871; signal transducer activity
GO:0004872; receptor activity
GO:0004888; transmembrane signaling receptor activity
GO:0005031; tumor necrosis factor-activated receptor activity
GO:0005515; protein binding
GO:0017137; Rab GTPase binding
GO:0031625; ubiquitin protein ligase binding
GO:0048406; nerve growth factor binding
Protein interactions and network
- Protein-protein interacting partners in GenAge
- SHC1, NGF, NGFR, H2AFX, CDKN1A, IKBKB, SQSTM1
- STRING interaction network
Retrieve sequences for NGFR
Homologs in model organisms
- Danio rerio
- uncharacterized_F1R8
- Mus musculus
- Ngfr
- Rattus norvegicus
- Ngfr