GenAge entry for PIK3CB (Homo sapiens)

Gene name (HAGRID: 36)

HGNC symbol: PIK3CB
Aliases: PIK3C1
Common name: phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit beta

Potential relevance to the human ageing process

Main reason for selection: Entry selected based on evidence directly linking the gene product to ageing in a non-mammalian animal model
Description: PIK3CB is involved in the signal transduction of insulin (INS) and insulin-like pathways including the activation of the MAPK pathway [154]. A homologue of PIK3CB, age-1, has been related to ageing in roundworms [1518]. Genotype combinations in the human PIK3CB and IGF1R genes have been related to plasma IGF1 levels and longevity [141], though the elucidation of PIK3CB's role in ageing will require more detailed studies.

Cytogenetic information

Cytogenetic band: 3q22.3
Location: 138,652,698 bp to 138,759,359 bp
Orientation: Minus strand

Display region using the UCSC Genome Browser (GRCh38/hg38)

Protein information

Gene Ontology

Process:

GO:0000187; activation of MAPK activity
GO:0001935; endothelial cell proliferation
GO:0001952; regulation of cell-matrix adhesion
GO:0006661; phosphatidylinositol biosynthetic process
GO:0006874; cellular calcium ion homeostasis
GO:0006914; autophagy
GO:0006935; chemotaxis
GO:0007156; homophilic cell adhesion via plasma membrane adhesion molecules
GO:0007165; signal transduction
GO:0007169; transmembrane receptor protein tyrosine kinase signaling pathway
GO:0007186; G-protein coupled receptor signaling pathway
GO:0010508; positive regulation of autophagy
GO:0010628; positive regulation of gene expression
GO:0014065; phosphatidylinositol 3-kinase signaling
GO:0014066; regulation of phosphatidylinositol 3-kinase signaling
GO:0016310; phosphorylation
GO:0016477; cell migration
GO:0030168; platelet activation
GO:0036092; phosphatidylinositol-3-phosphate biosynthetic process
GO:0038095; Fc-epsilon receptor signaling pathway
GO:0038096; Fc-gamma receptor signaling pathway involved in phagocytosis
GO:0040016; embryonic cleavage
GO:0046854; phosphatidylinositol phosphorylation
GO:0048010; vascular endothelial growth factor receptor signaling pathway
GO:0048015; phosphatidylinositol-mediated signaling
GO:0050852; T cell receptor signaling pathway
GO:0050900; leukocyte migration
GO:0060055; angiogenesis involved in wound healing
GO:0070527; platelet aggregation
GO:2000369; regulation of clathrin-dependent endocytosis

Cellular component:

GO:0005634; nucleus
GO:0005730; nucleolus
GO:0005829; cytosol
GO:0005886; plasma membrane
GO:0005942; phosphatidylinositol 3-kinase complex
GO:0045171; intercellular bridge

Function:

GO:0005515; protein binding
GO:0005524; ATP binding
GO:0016301; kinase activity
GO:0016303; 1-phosphatidylinositol-3-kinase activity
GO:0035004; phosphatidylinositol 3-kinase activity
GO:0035005; 1-phosphatidylinositol-4-phosphate 3-kinase activity
GO:0043560; insulin receptor substrate binding
GO:0046934; phosphatidylinositol-4,5-bisphosphate 3-kinase activity

Hide GO terms

Protein interactions and network

Protein-protein interacting partners in GenAge: IRS1, AKT1, EGFR, PRKCD, GRB2, PIK3R1
STRING interaction network

Retrieve sequences for PIK3CB

ORF: ORF
CDS: CDS

Homologs in model organisms

Danio rerio: pik3cb
Drosophila melanogaster: Pi3K92E
Mus musculus: Pik3cb
Rattus norvegicus: Pik3cb

In other databases

GenAge model organism genes

A homolog of this gene for Drosophila melanogaster is present as Pi3K92E

LongevityMap

This gene is present as PIK3CB