GenAge entry for PRKCD (Homo sapiens)

Gene name (HAGRID: 54)

HGNC symbol: PRKCD
Aliases
Common name: protein kinase C, delta

Potential relevance to the human ageing process

Main reason for selection: Entry selected based on evidence showing that the gene product to be a target of genes previously linked to ageing
Description: Involved in the regulation of growth, apoptosis, and differentiation of a variety of cell types [388], PRKCD may influence age-related changes at the CNS and immune system level [387].

Cytogenetic information

Cytogenetic band: 3p21.31
Location: 53,161,207 bp to 53,192,717 bp
Orientation: Plus strand

Display region using the UCSC Genome Browser (GRCh38/hg38)

Protein information

Gene Ontology

Process:

GO:0002223; stimulatory C-type lectin receptor signaling pathway
GO:0006468; protein phosphorylation
GO:0006915; apoptotic process
GO:0006921; cellular component disassembly involved in execution phase of apoptosis
GO:0007049; cell cycle
GO:0007165; signal transduction
GO:0007202; activation of phospholipase C activity
GO:0008631; intrinsic apoptotic signaling pathway in response to oxidative stress
GO:0010469; regulation of receptor activity
GO:0016064; immunoglobulin mediated immune response
GO:0016572; histone phosphorylation
GO:0018105; peptidyl-serine phosphorylation
GO:0018107; peptidyl-threonine phosphorylation
GO:0018108; peptidyl-tyrosine phosphorylation
GO:0023021; termination of signal transduction
GO:0030168; platelet activation
GO:0030837; negative regulation of actin filament polymerization
GO:0032079; positive regulation of endodeoxyribonuclease activity
GO:0032091; negative regulation of protein binding
GO:0032147; activation of protein kinase activity
GO:0032613; interleukin-10 production
GO:0032615; interleukin-12 production
GO:0032930; positive regulation of superoxide anion generation
GO:0032956; regulation of actin cytoskeleton organization
GO:0034351; negative regulation of glial cell apoptotic process
GO:0035307; positive regulation of protein dephosphorylation
GO:0038096; Fc-gamma receptor signaling pathway involved in phagocytosis
GO:0042100; B cell proliferation
GO:0042119; neutrophil activation
GO:0042307; positive regulation of protein import into nucleus
GO:0042742; defense response to bacterium
GO:0043407; negative regulation of MAP kinase activity
GO:0043488; regulation of mRNA stability
GO:0046627; negative regulation of insulin receptor signaling pathway
GO:0050728; negative regulation of inflammatory response
GO:0050732; negative regulation of peptidyl-tyrosine phosphorylation
GO:0050821; protein stabilization
GO:0051490; negative regulation of filopodium assembly
GO:0060326; cell chemotaxis
GO:0060333; interferon-gamma-mediated signaling pathway
GO:0070301; cellular response to hydrogen peroxide
GO:0071447; cellular response to hydroperoxide
GO:0090331; negative regulation of platelet aggregation
GO:0090398; cellular senescence
GO:1900163; positive regulation of phospholipid scramblase activity
GO:1904385; cellular response to angiotensin
GO:2000304; positive regulation of ceramide biosynthetic process
GO:2000753; positive regulation of glucosylceramide catabolic process
GO:2000755; positive regulation of sphingomyelin catabolic process
GO:2001022; positive regulation of response to DNA damage stimulus
GO:2001235; positive regulation of apoptotic signaling pathway

Cellular component:

GO:0005634; nucleus
GO:0005654; nucleoplasm
GO:0005737; cytoplasm
GO:0005783; endoplasmic reticulum
GO:0005829; cytosol
GO:0005886; plasma membrane
GO:0005911; cell-cell junction
GO:0016363; nuclear matrix
GO:0048471; perinuclear region of cytoplasm
GO:0070062; extracellular exosome

Function:

GO:0004672; protein kinase activity
GO:0004674; protein serine/threonine kinase activity
GO:0004697; protein kinase C activity
GO:0004699; calcium-independent protein kinase C activity
GO:0004715; non-membrane spanning protein tyrosine kinase activity
GO:0005515; protein binding
GO:0005524; ATP binding
GO:0008047; enzyme activator activity
GO:0019899; enzyme binding
GO:0019900; kinase binding
GO:0019901; protein kinase binding
GO:0043560; insulin receptor substrate binding
GO:0046872; metal ion binding

Hide GO terms

Protein interactions and network

Protein-protein interacting partners in GenAge: SHC1, TP53, STAT3, IRS1, PIK3CB, MYC, INSR, PRKCD, VCP, HSP90AA1, PDPK1, EP300, APP, YWHAZ, PTK2B, SP1, MTOR, NFE2L2, GSK3A, IKBKB, SQSTM1
STRING interaction network

Retrieve sequences for PRKCD

ORF: ORF
CDS: CDS

Homologs in model organisms

Danio rerio: BX005175.1
Mus musculus: Prkcd
Rattus norvegicus: Prkcd
Schizosaccharomyces pombe: pck1

In other databases

CellAge

This gene is present as PRKCD