GenAge entry for PDPK1 (Homo sapiens)
Gene name (HAGRID: 87)
- HGNC symbol
- PDPK1
- Aliases
- PDK1
- Common name
- 3-phosphoinositide dependent protein kinase 1
Potential relevance to the human ageing process
- Main reason for selection
- Entry selected based on evidence showing that the gene product to be a target of genes previously linked to ageing
- Description
PDPK1 phosphorylates and activates AKT1, among other proteins, and appears to play a role in signal transduction and development, maybe by mediating the activation of AKT1 by growth factors. The PDPK1 encodes three isoforms. In roundworms, PDPK1 has been associated with signals related to development and longevity [948]. Mice without PDPK1 die at embryonic stages, though mice with low levels of PDPK1 are viable and fertile despite a small body size [1633].
Cytogenetic information
- Cytogenetic band
- 16p13.3
- Location
- 2,537,964 bp to 2,603,190 bp
- Orientation
- Plus strand
Protein information
- Gene Ontology
-
Process: GO:0002223; stimulatory C-type lectin receptor signaling pathway
GO:0003323; type B pancreatic cell development
GO:0006351; transcription, DNA-templated
GO:0006355; regulation of transcription, DNA-templated
GO:0006468; protein phosphorylation
GO:0006469; negative regulation of protein kinase activity
GO:0006972; hyperosmotic response
GO:0007173; epidermal growth factor receptor signaling pathway
GO:0010518; positive regulation of phospholipase activity
GO:0010594; regulation of endothelial cell migration
GO:0010667; negative regulation of cardiac muscle cell apoptotic process
And 26 more GO terms Cellular component: GO:0005622; intracellular
GO:0005654; nucleoplasm
GO:0005737; cytoplasm
GO:0005829; cytosol
GO:0005886; plasma membrane
GO:0005925; focal adhesion
GO:0014069; postsynaptic density
GO:0016020; membrane
GO:0031410; cytoplasmic vesicle
GO:0042995; cell projection
GO:0043204; perikaryon
And 1 more GO terms Function: GO:0004674; protein serine/threonine kinase activity
GO:0004676; 3-phosphoinositide-dependent protein kinase activity
GO:0005158; insulin receptor binding
GO:0005515; protein binding
GO:0005524; ATP binding
GO:0016004; phospholipase activator activity
GO:0016301; kinase activity
GO:0019901; protein kinase binding
GO:0043274; phospholipase binding
Protein interactions and network
- Protein-protein interacting partners in GenAge
- AKT1, PRKCD, PDPK1, XRCC6, APP, MAPK8
- STRING interaction network