GenAge entry for RAD51 (Homo sapiens)

Gene name (HAGRID: 84)

HGNC symbol: RAD51
Aliases: HsRad51; HsT16930; BRCC5; FANCR; RAD51A; RECA
Common name: RAD51 recombinase

Potential relevance to the human ageing process

Main reason for selection: Entry selected based on evidence directly linking the gene product to ageing in a cellular model system
Description: Involved in DNA unwinding and repair [489], RAD51 has been reported to be an important player in the cellular senescence of yeast [192]. Disruption of RAD51 in mice results in embryonic lethality [488]. Its role in mammalian ageing remains unknown.

Cytogenetic information

Cytogenetic band: 15q15.1
Location: 40,695,129 bp to 40,732,158 bp
Orientation: Plus strand

Display region using the UCSC Genome Browser (GRCh38/hg38)

Protein information

Gene Ontology

Process:

GO:0000722; telomere maintenance via recombination
GO:0000724; double-strand break repair via homologous recombination
GO:0000730; DNA recombinase assembly
GO:0000731; DNA synthesis involved in DNA repair
GO:0000732; strand displacement
GO:0001932; regulation of protein phosphorylation
GO:0006268; DNA unwinding involved in DNA replication
GO:0006281; DNA repair
GO:0006310; DNA recombination
GO:0006312; mitotic recombination
GO:0006974; cellular response to DNA damage stimulus
GO:0007126; meiotic nuclear division
GO:0007131; reciprocal meiotic recombination
GO:0009636; response to toxic substance
GO:0010165; response to X-ray
GO:0010569; regulation of double-strand break repair via homologous recombination
GO:0010833; telomere maintenance via telomere lengthening
GO:0031297; replication fork processing
GO:0036297; interstrand cross-link repair
GO:0042148; strand invasion
GO:0042493; response to drug
GO:0051106; positive regulation of DNA ligation
GO:0051260; protein homooligomerization
GO:0070192; chromosome organization involved in meiotic cell cycle
GO:0071479; cellular response to ionizing radiation
GO:0071480; cellular response to gamma radiation
GO:0072711; cellular response to hydroxyurea
GO:0072719; cellular response to cisplatin
GO:0072757; cellular response to camptothecin
GO:1904631; response to glucoside
GO:1990414; replication-born double-strand break repair via sister chromatid exchange
GO:1990426; mitotic recombination-dependent replication fork processing

Cellular component:

GO:0000228; nuclear chromosome
GO:0000784; nuclear chromosome, telomeric region
GO:0000785; chromatin
GO:0000790; nuclear chromatin
GO:0000793; condensed chromosome
GO:0000794; condensed nuclear chromosome
GO:0000800; lateral element
GO:0005634; nucleus
GO:0005654; nucleoplasm
GO:0005730; nucleolus
GO:0005737; cytoplasm
GO:0005739; mitochondrion
GO:0005759; mitochondrial matrix
GO:0005815; microtubule organizing center
GO:0016605; PML body
GO:0035861; site of double-strand break
GO:0048471; perinuclear region of cytoplasm

Function:

GO:0000150; recombinase activity
GO:0000400; four-way junction DNA binding
GO:0003682; chromatin binding
GO:0003690; double-stranded DNA binding
GO:0003697; single-stranded DNA binding
GO:0004520; endodeoxyribonuclease activity
GO:0005515; protein binding
GO:0005524; ATP binding
GO:0008022; protein C-terminus binding
GO:0042802; identical protein binding
GO:0043142; single-stranded DNA-dependent ATPase activity
GO:0070182; DNA polymerase binding

Hide GO terms

Protein interactions and network

Protein-protein interacting partners in GenAge: TP53, ATM, WRN, BRCA1, RPA1, BLM, HSP90AA1, ABL1, BRCA2, RAD51, UBE2I, PML, PCNA, RAD52, SP1, SUMO1, H2AFX, ESR1, CDC42
STRING interaction network

Retrieve sequences for RAD51

Promoter: Promoter
ORF: ORF
CDS: CDS

Homologs in model organisms

Caenorhabditis elegans: rad-51
Danio rerio: rad51
Drosophila melanogaster: spn-A
Mus musculus: Rad51
Rattus norvegicus: LOC100911267
Saccharomyces cerevisiae: RAD51
Schizosaccharomyces pombe: rhp51

In other databases

GenAge model organism genes

A homolog of this gene for Saccharomyces cerevisiae is present as RAD51

LongevityMap

This gene is present as RAD51

CellAge gene expression

This gene is present as RAD51