GenAge entry for RICTOR (Homo sapiens)

Gene name (HAGRID: 303)

HGNC symbol: RICTOR
Aliases: MGC39830; AVO3; PIA; KIAA1999
Common name: RPTOR independent companion of MTOR, complex 2

Potential relevance to the human ageing process

Main reason for selection: Entry selected based on evidence linking the gene product to a pathway or mechanism linked to ageing
Description: RICTOR is a protein component of MTOR Complex 2 (mTORC2) that is essential for its activity. Heterozygous male Rictor mice display a significantly decrease in median lifespan (40%) compared to wild-type controls. Liver-specific deletion of Rictor in male mice also resulted in a 30% decrease in median lifespan. In both models, the decrease in lifespan was associated with a decrease in the incidence of cancer. Inducibly deleting Rictor throughout the body in adult animals results in a stronger phenotype with a median survival of less than 1 year. No significant changes were observed for female lifespan in any of the three models. While the mechanism by which RICTOR depletion shortens male lifespan remains unknown, it seems that it is independent of the glucose tolerance role of hepatic mTORC2 and that calorie restriction does not rescue the phenotype [3486].

Cytogenetic information

Cytogenetic band: 5p13.1
Location: 38,937,921 bp to 39,074,408 bp
Orientation: Minus strand

Display region using the UCSC Genome Browser (GRCh38/hg38)

Protein information

Gene Ontology

Process:

GO:0001938; positive regulation of endothelial cell proliferation
GO:0009790; embryo development
GO:0010468; regulation of gene expression
GO:0018105; peptidyl-serine phosphorylation
GO:0030010; establishment of cell polarity
GO:0030838; positive regulation of actin filament polymerization
GO:0030950; establishment or maintenance of actin cytoskeleton polarity
GO:0031295; T cell costimulation
GO:0031532; actin cytoskeleton reorganization
GO:0031929; TOR signaling
GO:0032008; positive regulation of TOR signaling
GO:0032956; regulation of actin cytoskeleton organization
GO:0033135; regulation of peptidyl-serine phosphorylation
GO:0042325; regulation of phosphorylation
GO:0043085; positive regulation of catalytic activity
GO:0043087; regulation of GTPase activity
GO:0048015; phosphatidylinositol-mediated signaling
GO:0050727; regulation of inflammatory response
GO:0050731; positive regulation of peptidyl-tyrosine phosphorylation
GO:0051896; regulation of protein kinase B signaling
GO:0051897; positive regulation of protein kinase B signaling
GO:2000114; regulation of establishment of cell polarity

Cellular component:

GO:0005829; cytosol
GO:0031932; TORC2 complex

Function:

GO:0005515; protein binding
GO:0008047; enzyme activator activity
GO:0019901; protein kinase binding
GO:0043022; ribosome binding

Hide GO terms

Protein interactions and network

Protein-protein interacting partners in GenAge: AKT1, NBN, BRCA1, GSK3B, PRKCA, SIRT1, MAPK14, MTOR, GSK3A, IKBKB
STRING interaction network

Retrieve sequences for RICTOR

ORF: ORF
CDS: CDS

Homologs in model organisms

Caenorhabditis elegans: rict-1
Danio rerio: rictorb
Drosophila melanogaster: rictor
Mus musculus: Rictor
Rattus norvegicus: Rictor
Saccharomyces cerevisiae: TSC11
Schizosaccharomyces pombe: ste16

In other databases

GenAge model organism genes

A homolog of this gene for Mus musculus is present as Rictor
A homolog of this gene for Caenorhabditis elegans is present as rict-1

LongevityMap

This gene is present as RICTOR