GenAge entry for SIN3A (Homo sapiens)

Gene name (HAGRID: 200)

HGNC symbol: SIN3A
Aliases: KIAA0700; DKFZP434K2235
Common name: SIN3 transcription regulator family member A

Potential relevance to the human ageing process

Main reason for selection: Entry selected based on indirect or inconclusive evidence linking the gene product to ageing in humans or in one or more model systems
Description: SIN3A is a transcriptional regulator that interacts with MXI1 to antagonize MYC [982]. Neuronal apoptosis has been related to elevated SIN3A levels [1735], though SIN3A expression levels did not increase with age in rats [873]. SIN3A has not been directly related to human ageing.

Cytogenetic information

Cytogenetic band: 15q24.2
Location: 75,369,379 bp to 75,451,585 bp
Orientation: Minus strand

Display region using the UCSC Genome Browser (GRCh38/hg38)

Protein information

Gene Ontology

Process:

GO:0000122; negative regulation of transcription from RNA polymerase II promoter
GO:0001701; in utero embryonic development
GO:0002218; activation of innate immune response
GO:0002230; positive regulation of defense response to virus by host
GO:0002244; hematopoietic progenitor cell differentiation
GO:0006260; DNA replication
GO:0006351; transcription, DNA-templated
GO:0006476; protein deacetylation
GO:0007568; aging
GO:0010817; regulation of hormone levels
GO:0010971; positive regulation of G2/M transition of mitotic cell cycle
GO:0016575; histone deacetylation
GO:0031937; positive regulation of chromatin silencing
GO:0034613; cellular protein localization
GO:0042754; negative regulation of circadian rhythm
GO:0043066; negative regulation of apoptotic process
GO:0043619; regulation of transcription from RNA polymerase II promoter in response to oxidative stress
GO:0044255; cellular lipid metabolic process
GO:0045892; negative regulation of transcription, DNA-templated
GO:0045944; positive regulation of transcription from RNA polymerase II promoter
GO:0048511; rhythmic process
GO:0051595; response to methylglyoxal
GO:0071333; cellular response to glucose stimulus
GO:1900181; negative regulation of protein localization to nucleus
GO:1901675; negative regulation of histone H3-K27 acetylation
GO:1903351; cellular response to dopamine
GO:2000678; negative regulation of transcription regulatory region DNA binding

Cellular component:

GO:0000776; kinetochore
GO:0005634; nucleus
GO:0005654; nucleoplasm
GO:0005667; transcription factor complex
GO:0005730; nucleolus
GO:0005737; cytoplasm
GO:0016580; Sin3 complex
GO:0017053; transcriptional repressor complex
GO:0045171; intercellular bridge

Function:

GO:0000976; transcription regulatory region sequence-specific DNA binding
GO:0001102; RNA polymerase II activating transcription factor binding
GO:0001103; RNA polymerase II repressing transcription factor binding
GO:0001106; RNA polymerase II transcription corepressor activity
GO:0003682; chromatin binding
GO:0003700; transcription factor activity, sequence-specific DNA binding
GO:0003723; RNA binding
GO:0004407; histone deacetylase activity
GO:0005515; protein binding
GO:0032403; protein complex binding
GO:0033558; protein deacetylase activity

Hide GO terms

Protein interactions and network

Protein-protein interacting partners in GenAge: TP53, STAT3, NCOR1, HIF1A, HSP90AA1, PML, AR, HDAC1, SP1, TAF1, TBP, HBP1, HDAC2, MAX, MXD1, ESR1, NCOR2
STRING interaction network

Retrieve sequences for SIN3A

ORF: ORF
CDS: CDS

Homologs in model organisms

Caenorhabditis elegans: sin-3
Danio rerio: sin3aa
Drosophila melanogaster: Sin3A
Mus musculus: Sin3a
Rattus norvegicus: Sin3a