GenAge entry for STUB1 (Homo sapiens)

Entry selected based on evidence directly linking the gene product to ageing in a mammalian model organism

Gene name (HAGRID: 245)

HGNC symbol: STUB1
Aliases: UBOX1; CHIP; SDCCAG7; HSPABP2; NY-CO-7
Common name: STIP1 homology and U-box containing protein 1, E3 ubiquitin protein ligase

Potential relevance to the human ageing process

Main reason for selection

Entry selected based on evidence directly linking the gene product to ageing in a mammalian model organism

Description

STUB1 is involved in proteasomal degradation by targeting misfolded chaperone substrates and interacting with chaperone complexes, including HSPA8, thus contributing to protein quality control.

STUB1-null mice exhibit a deregulation of protein quality control. They have a short lifespan and accelerated age-related pathophysiological features [1836], suggesting a potential role of STUB1 in ageing.

Cytogenetic information

Cytogenetic band: 16p13.3
Location: 680,111 bp to 682,768 bp
Orientation: Plus strand

Display region using the UCSC Genome Browser (GRCh38/hg38)

Protein information

Gene Ontology

Process:

GO:0000209; protein polyubiquitination
GO:0006281; DNA repair
GO:0006511; ubiquitin-dependent protein catabolic process
GO:0006515; misfolded or incompletely synthesized protein catabolic process
GO:0016567; protein ubiquitination
GO:0030512; negative regulation of transforming growth factor beta receptor signaling pathway
GO:0030579; ubiquitin-dependent SMAD protein catabolic process
GO:0030968; endoplasmic reticulum unfolded protein response
GO:0031398; positive regulation of protein ubiquitination
GO:0031647; regulation of protein stability
GO:0031943; regulation of glucocorticoid metabolic process
GO:0032091; negative regulation of protein binding
GO:0032436; positive regulation of proteasomal ubiquitin-dependent protein catabolic process
GO:0036503; ERAD pathway
GO:0038128; ERBB2 signaling pathway
GO:0042787; protein ubiquitination involved in ubiquitin-dependent protein catabolic process
GO:0043161; proteasome-mediated ubiquitin-dependent protein catabolic process
GO:0051443; positive regulation of ubiquitin-protein transferase activity
GO:0051604; protein maturation
GO:0051865; protein autoubiquitination
GO:0070534; protein K63-linked ubiquitination
GO:0071218; cellular response to misfolded protein
GO:0090035; positive regulation of chaperone-mediated protein complex assembly

Cellular component:

GO:0000151; ubiquitin ligase complex
GO:0005654; nucleoplasm
GO:0005737; cytoplasm
GO:0005783; endoplasmic reticulum
GO:0005829; cytosol
GO:0005886; plasma membrane
GO:0030018; Z disc
GO:0031371; ubiquitin conjugating enzyme complex
GO:0042405; nuclear inclusion body
GO:0045111; intermediate filament cytoskeleton
GO:0070062; extracellular exosome

Function:

GO:0001664; G-protein coupled receptor binding
GO:0004842; ubiquitin-protein transferase activity
GO:0005515; protein binding
GO:0016874; ligase activity
GO:0019899; enzyme binding
GO:0019900; kinase binding
GO:0030544; Hsp70 protein binding
GO:0030674; protein binding, bridging
GO:0030911; TPR domain binding
GO:0031625; ubiquitin protein ligase binding
GO:0034450; ubiquitin-ubiquitin ligase activity
GO:0042803; protein homodimerization activity
GO:0046332; SMAD binding
GO:0051787; misfolded protein binding
GO:0051879; Hsp90 protein binding
GO:0061630; ubiquitin protein ligase activity
GO:1904264; ubiquitin protein ligase activity involved in ERAD pathway

Hide GO terms

Protein interactions and network

Protein-protein interacting partners in GenAge: GHR, TP53, TERT, AKT1, MYC, EGFR, ERBB2, PTEN, HIF1A, VCP, HSP90AA1, NR3C1, ABL1, STK11, TERF1, AR, TERF2, FOXO1, HSF1, SOD1, APP, RELA, HSPD1, HSPA1A, HSPA1B, PTK2, MAP3K5, HSPA8, MAPT, ESR1, POLB, SIRT6, STUB1, MIF, SQSTM1
STRING interaction network

Retrieve sequences for STUB1

Promoter: Promoter
ORF: ORF
CDS: CDS

Homologs in model organisms

Caenorhabditis elegans: chn-1
Danio rerio: stub1
Drosophila melanogaster: CHIP
Mus musculus: Stub1
Rattus norvegicus: Stub1

In other databases

GenAge model organism genes

A homolog of this gene for Mus musculus is present as Stub1
A homolog of this gene for Caenorhabditis elegans is present as chn-1

CellAge

This gene is present as STUB1