GenAge entry for TERF1 (Homo sapiens)

Gene name (HAGRID: 105)

HGNC symbol: TERF1
Aliases: PIN2; TRF1; TRF; TRBF1
Common name: telomeric repeat binding factor (NIMA-interacting) 1

Potential relevance to the human ageing process

Main reason for selection: Entry selected based on evidence linking the gene product to a pathway or mechanism linked to ageing
Description: TERF1 associates with the telomeres and appears to be an important regulator of telomere biology [73]. Expression of TERF1 in mice prevented age-related decline in neuromuscular function, glucose homeostasis, cognitive function, lipid stores, and chronic anemia [4503]. Though, its role in human ageing is unknown, TERF1 levels decrease with ageing in both mice and humans.

Cytogenetic information

Cytogenetic band: 8q21.11
Location: 73,008,862 bp to 73,047,752 bp
Orientation: Plus strand

Display region using the UCSC Genome Browser (GRCh38/hg38)

Protein information

Gene Ontology

Process:

GO:0000723; telomere maintenance
GO:0007004; telomere maintenance via telomerase
GO:0007067; mitotic nuclear division
GO:0008156; negative regulation of DNA replication
GO:0016233; telomere capping
GO:0031627; telomeric loop formation
GO:0032211; negative regulation of telomere maintenance via telomerase
GO:0032214; negative regulation of telomere maintenance via semi-conservative replication
GO:0042493; response to drug
GO:0045141; meiotic telomere clustering
GO:0051301; cell division
GO:0051974; negative regulation of telomerase activity
GO:1904792; positive regulation of telosome assembly
GO:1904850; negative regulation of establishment of protein localization to telomere
GO:1904911; negative regulation of establishment of RNA localization to telomere
GO:1904914; negative regulation of establishment of macromolecular complex localization to telomere

Cellular component:

GO:0000783; nuclear telomere cap complex
GO:0000784; nuclear chromosome, telomeric region
GO:0005634; nucleus
GO:0005654; nucleoplasm
GO:0005730; nucleolus
GO:0005737; cytoplasm
GO:0005819; spindle
GO:0070187; telosome

Function:

GO:0003677; DNA binding
GO:0003691; double-stranded telomeric DNA binding
GO:0003720; telomerase activity
GO:0005515; protein binding
GO:0008301; DNA binding, bending
GO:0042162; telomeric DNA binding
GO:0042803; protein homodimerization activity
GO:0043130; ubiquitin binding
GO:0098505; G-rich strand telomeric DNA binding

Hide GO terms

Protein interactions and network

Protein-protein interacting partners in GenAge: TERT, ATM, NBN, BRCA1, BLM, HSP90AA1, ABL1, EP300, TERF1, PRKDC, XRCC5, FEN1, TERF2, RECQL4, FOXM1, SNCG, PRDX1, GSS, PCMT1, APEX1, MTOR, DBN1, STUB1
STRING interaction network

Retrieve sequences for TERF1

ORF: ORF
CDS: CDS

Homologs in model organisms

Danio rerio: terf1
Mus musculus: Terf1
Rattus norvegicus: Terf1

In other databases

LongevityMap

This gene is present as TERF1