GenAge entry for VCP (Homo sapiens)

Gene name (HAGRID: 71)

HGNC symbol: VCP
Aliases: IBMPFD; p97
Common name: valosin containing protein

Potential relevance to the human ageing process

Main reason for selection: Entry selected based on evidence showing that the gene product to be a target of genes previously linked to ageing
Description: Also known as p97, VCP is required for the export of endoplasmic reticulum proteins into the cytosol [455]. Its interaction with WRN and a possible role in WRN's DNA damage response pathway makes it an intriguing protein [454], even though it has not been directly linked to ageing.

Cytogenetic information

Cytogenetic band: 9p13.3
Location: 35,056,068 bp to 35,072,742 bp
Orientation: Minus strand

Display region using the UCSC Genome Browser (GRCh38/hg38)

Protein information

Gene Ontology

Process:

GO:0006281; DNA repair
GO:0006302; double-strand break repair
GO:0006734; NADH metabolic process
GO:0006888; ER to Golgi vesicle-mediated transport
GO:0006914; autophagy
GO:0006919; activation of cysteine-type endopeptidase activity involved in apoptotic process
GO:0006974; cellular response to DNA damage stimulus
GO:0010918; positive regulation of mitochondrial membrane potential
GO:0016567; protein ubiquitination
GO:0018279; protein N-linked glycosylation via asparagine
GO:0019079; viral genome replication
GO:0019985; translesion synthesis
GO:0030433; ER-associated ubiquitin-dependent protein catabolic process
GO:0030968; endoplasmic reticulum unfolded protein response
GO:0030970; retrograde protein transport, ER to cytosol
GO:0031334; positive regulation of protein complex assembly
GO:0032436; positive regulation of proteasomal ubiquitin-dependent protein catabolic process
GO:0034214; protein hexamerization
GO:0036503; ERAD pathway
GO:0042981; regulation of apoptotic process
GO:0043161; proteasome-mediated ubiquitin-dependent protein catabolic process
GO:0045184; establishment of protein localization
GO:0045732; positive regulation of protein catabolic process
GO:0046034; ATP metabolic process
GO:0051260; protein homooligomerization
GO:0070842; aggresome assembly
GO:0070987; error-free translesion synthesis
GO:0071712; ER-associated misfolded protein catabolic process
GO:0072389; flavin adenine dinucleotide catabolic process
GO:0097352; autophagosome maturation
GO:1903006; positive regulation of protein K63-linked deubiquitination
GO:1903007; positive regulation of Lys63-specific deubiquitinase activity
GO:1903715; regulation of aerobic respiration
GO:1903862; positive regulation of oxidative phosphorylation
GO:2000158; positive regulation of ubiquitin-specific protease activity
GO:2001171; positive regulation of ATP biosynthetic process

Cellular component:

GO:0000502; proteasome complex
GO:0005634; nucleus
GO:0005654; nucleoplasm
GO:0005737; cytoplasm
GO:0005783; endoplasmic reticulum
GO:0005789; endoplasmic reticulum membrane
GO:0005811; lipid particle
GO:0005829; cytosol
GO:0034098; VCP-NPL4-UFD1 AAA ATPase complex
GO:0035861; site of double-strand break
GO:0036513; Derlin-1 retrotranslocation complex
GO:0043209; myelin sheath
GO:0043231; intracellular membrane-bounded organelle
GO:0048471; perinuclear region of cytoplasm
GO:0070062; extracellular exosome
GO:1990730; VCP-NSFL1C complex

Function:

GO:0005515; protein binding
GO:0005524; ATP binding
GO:0008289; lipid binding
GO:0016887; ATPase activity
GO:0019903; protein phosphatase binding
GO:0019904; protein domain specific binding
GO:0031593; polyubiquitin binding
GO:0031625; ubiquitin protein ligase binding
GO:0035800; deubiquitinase activator activity
GO:0036435; K48-linked polyubiquitin binding
GO:0042288; MHC class I protein binding
GO:0042802; identical protein binding
GO:0043531; ADP binding
GO:0044389; ubiquitin-like protein ligase binding
GO:0044822; poly(A) RNA binding
GO:1904288; BAT3 complex binding
GO:1990381; ubiquitin-specific protease binding

Hide GO terms

Protein interactions and network

Protein-protein interacting partners in GenAge: TP53, ERCC8, WRN, LMNA, NFKB2, AKT1, PRKCD, BRCA1, HIF1A, UBB, BLM, VCP, HSP90AA1, NFKB1, TOP1, ERCC6, HTT, HELLS, AR, TERF2, BAX, GRB2, HSPD1, HSPA1A, YWHAZ, MAPK3, PTGS2, HSPA8, CDK1, MDM2, SUMO1, ESR1, NFKBIA, MTOR, TP63, STUB1, CHEK2, SIRT7, TP53BP1, CDKN1A, HTRA2, SPRTN
STRING interaction network

Retrieve sequences for VCP

Promoter: Promoter
ORF: ORF
CDS: CDS

Homologs in model organisms

Caenorhabditis elegans: cdc-48.1
Danio rerio: vcp
Drosophila melanogaster: TER94
Mus musculus: Vcp
Rattus norvegicus: Vcp
Saccharomyces cerevisiae: CDC48
Schizosaccharomyces pombe: cdc48

In other databases

GenAge model organism genes

A homolog of this gene for Caenorhabditis elegans is present as cdc-48.1