GenAge entry for HOXB7 (Homo sapiens)
Gene name (HAGRID: 213)
- HGNC symbol
- HOXB7
- Aliases
- HOX2; HOX2C
- Common name
- homeobox B7
Potential relevance to the human ageing process
- Main reason for selection
- Entry selected based on indirect or inconclusive evidence linking the gene product to ageing in humans or in one or more model systems
- Description
HOXB7 is a member of the homeobox family, also called HOX, crucial in morphogenesis and development [1024]. The expression of many HOX genes, including HOXB7, declines with age, even prior to adulthood [1020]. An association of HOX genes with longevity has been proposed [1022], though there is no direct evidence linking HOXB7 to human ageing.
Cytogenetic information
- Cytogenetic band
- 17q21.3
- Location
- 48,607,233 bp to 48,611,021 bp
- Orientation
- Minus strand
Protein information
- Gene Ontology
-
Process: GO:0006351; transcription, DNA-templated
GO:0006355; regulation of transcription, DNA-templated
GO:0007275; multicellular organism development
GO:0009952; anterior/posterior pattern specification
GO:0030099; myeloid cell differentiation
GO:0048704; embryonic skeletal system morphogenesis
GO:0090190; positive regulation of branching involved in ureteric bud morphogenesis
Cellular component: GO:0005634; nucleus
GO:0005654; nucleoplasm
GO:0005737; cytoplasm
Show all GO termsFunction: GO:0003700; transcription factor activity, sequence-specific DNA binding
GO:0005515; protein binding
GO:0043565; sequence-specific DNA binding
Protein interactions and network
- Protein-protein interacting partners in GenAge
- PARP1, CREBBP, PRKDC, XRCC5, XRCC6, APP, NFKBIA
- STRING interaction network
