GenAge entry for TCF3 (Homo sapiens)

Gene name (HAGRID: 59)

HGNC symbol: TCF3
Aliases: E2A; ITF1; MGC129647; MGC129648; bHLHb21; VDIR; E47
Common name: transcription factor 3

Potential relevance to the human ageing process

Main reason for selection: Entry selected based on indirect or inconclusive evidence linking the gene product to ageing in humans or in one or more model systems
Description: A crucial protein in development, TCF3 may be involved in ageing of the immune system [1529].

Cytogenetic information

Cytogenetic band: 19p13.3
Location: 1,609,290 bp to 1,652,329 bp
Orientation: Minus strand

Display region using the UCSC Genome Browser (GRCh38/hg38)

Protein information

Gene Ontology

Process:

GO:0000122; negative regulation of transcription from RNA polymerase II promoter
GO:0002326; B cell lineage commitment
GO:0006351; transcription, DNA-templated
GO:0006355; regulation of transcription, DNA-templated
GO:0030183; B cell differentiation
GO:0033152; immunoglobulin V(D)J recombination
GO:0045666; positive regulation of neuron differentiation
GO:0045893; positive regulation of transcription, DNA-templated
GO:0045944; positive regulation of transcription from RNA polymerase II promoter
GO:0051091; positive regulation of sequence-specific DNA binding transcription factor activity
GO:0051149; positive regulation of muscle cell differentiation

And 1 more GO terms

Cellular component:

GO:0000790; nuclear chromatin
GO:0005634; nucleus
GO:0005654; nucleoplasm
GO:0005667; transcription factor complex
GO:0005737; cytoplasm
GO:0090575; RNA polymerase II transcription factor complex

Function:

GO:0000978; RNA polymerase II core promoter proximal region sequence-specific DNA binding
GO:0001078; transcriptional repressor activity, RNA polymerase II core promoter proximal region sequence-specific binding
GO:0003677; DNA binding
GO:0003700; transcription factor activity, sequence-specific DNA binding
GO:0003713; transcription coactivator activity
GO:0005515; protein binding
GO:0008134; transcription factor binding
GO:0031435; mitogen-activated protein kinase kinase kinase binding
GO:0035326; enhancer binding
GO:0042803; protein homodimerization activity
GO:0043425; bHLH transcription factor binding

And 5 more GO terms

Show all GO terms

Protein interactions and network

Protein-protein interacting partners in GenAge: TCF3, PARP1, CREBBP, UBE2I, EP300, RB1, HDAC2
STRING interaction network

Retrieve sequences for TCF3

ORF: ORF
CDS: CDS

Homologs in model organisms

Danio rerio: zgc:113045
Drosophila melanogaster: da
Mus musculus: Tcf3
Rattus norvegicus: Tcf3

In other databases

CellAge gene expression

This gene is present as TCF3