GenAge entry for CLU (Homo sapiens)

Gene name (HAGRID: 220)

HGNC symbol: CLU
Aliases: SGP-2; SP-40; TRPM-2; KUB1; CLU1; CLU2; CLI; APOJ
Common name: clusterin

Potential relevance to the human ageing process

Main reason for selection

Entry selected based on evidence directly linking the gene product to ageing in a non-mammalian animal model

Description

The functions of CLU are still unclear, but it may be involved in apoptosis. In flies, overexpression of human clusterin increased stress resistance and significantly extended lifespan [2116]. CLU-null mice had 50% less brain injury following neonatal hypoxia-ischemia [1748]. Inflammation was more severe in CLU-deficient mice [1749].

In humans, serum levels of CLU increase during type 2 diabetes and coronary heart disease [1230] and genome-wide association studies have identified variants of CLU to be associated with Alzheimer's disease [2003][2004]. There is however no direct evidence linking CLU to human ageing.

Cytogenetic information

Cytogenetic band: 8p21-p12
Location: 27,596,917 bp to 27,615,031 bp
Orientation: Minus strand

Display region using the UCSC Genome Browser (GRCh38/hg38)

Protein information

Gene Ontology

Process:

GO:0000902; cell morphogenesis
GO:0001774; microglial cell activation
GO:0001836; release of cytochrome c from mitochondria
GO:0002576; platelet degranulation
GO:0006629; lipid metabolic process
GO:0006956; complement activation
GO:0006958; complement activation, classical pathway
GO:0009615; response to virus
GO:0017038; protein import
GO:0032286; central nervous system myelin maintenance
GO:0032436; positive regulation of proteasomal ubiquitin-dependent protein catabolic process

And 22 more GO terms

Cellular component:	GO:0005576; extracellular region GO:0005615; extracellular space GO:0005634; nucleus GO:0005737; cytoplasm GO:0005739; mitochondrion GO:0005783; endoplasmic reticulum GO:0005794; Golgi apparatus GO:0005829; cytosol GO:0009986; cell surface GO:0031012; extracellular matrix GO:0031093; platelet alpha granule lumen
	And 10 more GO terms

Function:

GO:0005515; protein binding
GO:0016887; ATPase activity
GO:0031625; ubiquitin protein ligase binding
GO:0051087; chaperone binding
GO:0051787; misfolded protein binding

Show all GO terms

Protein interactions and network

Protein-protein interacting partners in GenAge: EGFR, FOS, NFKB1, TNF, XRCC6, BAX, GRB2, LRP2, APP, PON1, HSPD1, MAPK9, MDM2, H2AFX, NFKBIA, CLU, ELN, PDGFRA
STRING interaction network

Retrieve sequences for CLU

ORF: ORF
CDS: CDS

Homologs in model organisms

Danio rerio: clu
Mus musculus: Clu
Rattus norvegicus: Clu

In other databases

GenAge microarray genes

This gene is present as CLU

LongevityMap

This gene is present as CLU

CellAge

This gene is present as CLU