GenAge entry for FEN1 (Homo sapiens)

Gene name (HAGRID: 114)

HGNC symbol: FEN1
Aliases: FEN-1; MF1; RAD2
Common name: flap structure-specific endonuclease 1

Potential relevance to the human ageing process

Main reason for selection: Entry selected based on evidence showing that the gene product to be a target of genes previously linked to ageing
Description: Involved in DNA processing, FEN1 has been associated with cancer progression [586]. A FEN1 role in ageing is unknown, but due to its interactions with WRN [584] and PCNA [588], FEN1 might, in theory, be involved in human ageing.

Cytogenetic information

Cytogenetic band: 11q12
Location: 61,792,637 bp to 61,797,242 bp
Orientation: Plus strand

Display region using the UCSC Genome Browser (GRCh38/hg38)

Protein information

Gene Ontology

Process:

GO:0000722; telomere maintenance via recombination
GO:0000724; double-strand break repair via homologous recombination
GO:0006260; DNA replication
GO:0006281; DNA repair
GO:0006302; double-strand break repair
GO:0007613; memory
GO:0009650; UV protection
GO:0043137; DNA replication, removal of RNA primer
GO:0045876; positive regulation of sister chromatid cohesion
GO:0090305; nucleic acid phosphodiester bond hydrolysis
GO:0090502; RNA phosphodiester bond hydrolysis, endonucleolytic

And 1 more GO terms

Cellular component:

GO:0000784; nuclear chromosome, telomeric region
GO:0005634; nucleus
GO:0005654; nucleoplasm
GO:0005730; nucleolus
GO:0005739; mitochondrion
GO:0005886; plasma membrane
GO:0016020; membrane
GO:0043234; protein complex

Function:

GO:0003677; DNA binding
GO:0003684; damaged DNA binding
GO:0003690; double-stranded DNA binding
GO:0004519; endonuclease activity
GO:0004523; RNA-DNA hybrid ribonuclease activity
GO:0004527; exonuclease activity
GO:0005515; protein binding
GO:0008309; double-stranded DNA exodeoxyribonuclease activity
GO:0008409; 5'-3' exonuclease activity
GO:0017108; 5'-flap endonuclease activity
GO:0046872; metal ion binding

And 2 more GO terms

Show all GO terms

Protein interactions and network

Protein-protein interacting partners in GenAge: WRN, BLM, EP300, GSK3B, TERF1, PCNA, APP, CCNA2, FOXO4, APEX1, CDK1
STRING interaction network

Retrieve sequences for FEN1

Promoter: Promoter
ORF: ORF
CDS: CDS

Homologs in model organisms

Caenorhabditis elegans: crn-1
Danio rerio: fen1
Drosophila melanogaster: Fen1
Mus musculus: Fen1
Rattus norvegicus: Fen1
Saccharomyces cerevisiae: RAD27
Schizosaccharomyces pombe: rad2

In other databases

GenAge model organism genes

A homolog of this gene for Saccharomyces cerevisiae is present as RAD27

LongevityMap

This gene is present as FEN1

CellAge gene expression

This gene is present as FEN1