GenAge entry for SOD2 (Homo sapiens)
Entry selected based on evidence directly linking the gene product to ageing in a mammalian model organism
Gene name (HAGRID: 129)
- HGNC symbol
- SOD2
- Aliases
- Common name
- superoxide dismutase 2, mitochondrial
Potential relevance to the human ageing process
- Main reason for selection
- Entry selected based on evidence directly linking the gene product to ageing in a mammalian model organism
- Description
SOD2 is an antioxidant, the mitochondrial form of SOD and an important defence against oxidative damage. Evidence from invertebrates suggests it may play a role in ageing. Overexpression of SOD2 in flies significantly extends lifespan [1239]. Mice without SOD2 are not viable [658]. Reducing the activity of SOD2 in mice increases the levels of oxidative damage to DNA but does not affect lifespan [655]. SOD2 overexpression in mice slightly increases lifespan [1939], while gene deletion in connective tissue only resulted in mutant mice with a reduced lifespan and premature onset of aging-related phenotypes such as weight loss, skin atrophy, kyphosis, osteoporosis and muscle degeneration [1965]. Loss of SOD2 activity in the epidermis induces cellular senescence [4339]. In the long-lived alphaMUPA mice strain, a reduced level of SOD2 gene expression and activity is observed together with maintaining the capacity to produce high levels of SOD2 in response to the inflammatory stimulus [1561]. Exercise training elevates levels of SOD2 in aging mouse hearts. Overexpression of SOD2 in aging mouse hearts demonstrated a protective role against oxidative stress, fibrosis and apoptosis [4329]. Surprisingly, young mice with epidermal SOD2 deficiency have accelerated wound closure. In contrast, old mice with epidermal SOD2 deficiency show delayed wound closure, reduced epidermal thickness and epidermal stem cell exhaustion [4339].
Polymorphisms in the human SOD2 gene have been associated with type 2 diabetes [661] and cardiomyopathy [1693]. A longevity-associated polymorphism was observed for Ashkenazi males [1350], but not for Italian [2139] and Jordanian [2140] populations. Although it is possible that SOD2 plays a role in human ageing, further studies are needed to investigate this hypothesis.
Cytogenetic information
- Cytogenetic band
- 6q25.3
- Location
- 159,681,723 bp to 159,693,321 bp
- Orientation
- Minus strand
Protein information
- Gene Ontology
-
Process: GO:0000302; response to reactive oxygen species
GO:0000303; response to superoxide
GO:0001315; age-dependent response to reactive oxygen species
GO:0001836; release of cytochrome c from mitochondria
GO:0003069; vasodilation by acetylcholine involved in regulation of systemic arterial blood pressure
GO:0006357; regulation of transcription from RNA polymerase II promoter
GO:0006801; superoxide metabolic process
GO:0008217; regulation of blood pressure
GO:0008285; negative regulation of cell proliferation
GO:0019430; removal of superoxide radicals
GO:0032364; oxygen homeostasis
And 5 more GO terms Cellular component: GO:0005739; mitochondrion
GO:0005759; mitochondrial matrix
GO:0070062; extracellular exosome
Show all GO termsFunction: GO:0004784; superoxide dismutase activity
GO:0030145; manganese ion binding
GO:0042802; identical protein binding
Protein interactions and network
- Protein-protein interacting partners in GenAge
- CAT, SOD2, SOD1, APP, H2AFX, GPX4
- STRING interaction network
Retrieve sequences for SOD2
Homologs in model organisms
- Caenorhabditis elegans
- sod-3
- Danio rerio
- sod2
- Drosophila melanogaster
- Sod2
- Mus musculus
- Sod2
- Rattus norvegicus
- Sod2
- Saccharomyces cerevisiae
- SOD2
- Schizosaccharomyces pombe
- SPBC16A3.14
In other databases
- GenAge model organism genes
- GenDR gene manipulations
- A homolog of this gene for Saccharomyces cerevisiae is present as SOD2
- LongevityMap
- This gene is present as SOD2
- CellAge
- This gene is present as SOD2