GenAge entry for APEX1 (Homo sapiens)

Gene name (HAGRID: 195)

HGNC symbol: APEX1
Aliases: APE; REF1; HAP1; APX; APEN; REF-1; APE-1; APEX
Common name: APEX nuclease (multifunctional DNA repair enzyme) 1

Potential relevance to the human ageing process

Main reason for selection: Entry selected based on evidence linking the gene product to a pathway or mechanism linked to ageing
Description: APEX1 repairs oxidative DNA damage. Disruption of APEX1 in mice results in embryonic lethality [854]. Heterozygous mice had an elevated spontaneous mutation frequency [1732]. Whether APEX1 is involved in human ageing remains to be established.

Cytogenetic information

Cytogenetic band: 14q11.2
Location: 20,455,131 bp to 20,457,772 bp
Orientation: Plus strand

Display region using the UCSC Genome Browser (GRCh38/hg38)

Protein information

Gene Ontology

Process:

GO:0000723; telomere maintenance
GO:0006281; DNA repair
GO:0006284; base-excision repair
GO:0006286; base-excision repair, base-free sugar-phosphate removal
GO:0006310; DNA recombination
GO:0006351; transcription, DNA-templated
GO:0006355; regulation of transcription, DNA-templated
GO:0007568; aging
GO:0014912; negative regulation of smooth muscle cell migration
GO:0042493; response to drug
GO:0043488; regulation of mRNA stability
GO:0045454; cell redox homeostasis
GO:0045739; positive regulation of DNA repair
GO:0055114; oxidation-reduction process
GO:0070301; cellular response to hydrogen peroxide
GO:0071320; cellular response to cAMP
GO:0071375; cellular response to peptide hormone stimulus
GO:0080111; DNA demethylation
GO:0090502; RNA phosphodiester bond hydrolysis, endonucleolytic
GO:1900087; positive regulation of G1/S transition of mitotic cell cycle
GO:1903507; negative regulation of nucleic acid-templated transcription

Cellular component:

GO:0000784; nuclear chromosome, telomeric region
GO:0005634; nucleus
GO:0005654; nucleoplasm
GO:0005667; transcription factor complex
GO:0005730; nucleolus
GO:0005737; cytoplasm
GO:0005739; mitochondrion
GO:0005783; endoplasmic reticulum
GO:0005813; centrosome
GO:0005840; ribosome
GO:0016607; nuclear speck
GO:0048471; perinuclear region of cytoplasm

Function:

GO:0003677; DNA binding
GO:0003684; damaged DNA binding
GO:0003691; double-stranded telomeric DNA binding
GO:0003713; transcription coactivator activity
GO:0003714; transcription corepressor activity
GO:0003906; DNA-(apurinic or apyrimidinic site) lyase activity
GO:0004519; endonuclease activity
GO:0004520; endodeoxyribonuclease activity
GO:0004523; RNA-DNA hybrid ribonuclease activity
GO:0004528; phosphodiesterase I activity
GO:0004844; uracil DNA N-glycosylase activity
GO:0005515; protein binding
GO:0008081; phosphoric diester hydrolase activity
GO:0008309; double-stranded DNA exodeoxyribonuclease activity
GO:0008311; double-stranded DNA 3'-5' exodeoxyribonuclease activity
GO:0008408; 3'-5' exonuclease activity
GO:0016491; oxidoreductase activity
GO:0016890; site-specific endodeoxyribonuclease activity, specific for altered base
GO:0031490; chromatin DNA binding
GO:0032403; protein complex binding
GO:0044822; poly(A) RNA binding
GO:0046872; metal ion binding
GO:0051059; NF-kappaB binding

Hide GO terms

Protein interactions and network

Protein-protein interacting partners in GenAge: TP53, TXN, STAT3, HDAC3, HIF1A, RPA1, UBE2I, EP300, TERF1, XRCC5, PCNA, FEN1, TERF2, APP, SIRT1, HDAC1, HDAC2, MDM2, POLB, BUB3
STRING interaction network

Retrieve sequences for APEX1

Promoter: Promoter
ORF: ORF
CDS: CDS

Homologs in model organisms

Caenorhabditis elegans: exo-3
Danio rerio: apex1
Mus musculus: Apex1
Rattus norvegicus: Apex1

In other databases

GenAge model organism genes

A homolog of this gene for Caenorhabditis elegans is present as exo-3

LongevityMap

This gene is present as APEX1

CellAge

This gene is present as APEX1

CellAge gene expression

This gene is present as APEX1