GenAge entry for CDK7 (Homo sapiens)

Entry selected based on evidence directly linking the gene product to ageing in a mammalian model organism

Gene name (HAGRID: 299)

HGNC symbol: CDK7
Aliases: CAK1; CDKN7; MO15; STK1; CAK
Common name: cyclin-dependent kinase 7

Potential relevance to the human ageing process

Main reason for selection: Entry selected based on evidence directly linking the gene product to ageing in a mammalian model organism
Description: CDK7 is involved in cell cycle control and RNA transcription. Cdk7 deficiency causes early embryonic lethality. However, ablation of Cdk7 in adult animals results in age-related phenotypes, including weight loss, pervasive hair-greying, kyphosis and premature death with <20% of animals living more than one year [3262]. As such, CDK7 could play some role in human ageing, although further studies are necessary to explore this hypothesis.

Cytogenetic information

Cytogenetic band: 5q12.1
Location: 69,234,795 bp to 69,277,430 bp
Orientation: Plus strand

Display region using the UCSC Genome Browser (GRCh38/hg38)

Protein information

Gene Ontology

Process:

GO:0000079; regulation of cyclin-dependent protein serine/threonine kinase activity
GO:0000082; G1/S transition of mitotic cell cycle
GO:0000086; G2/M transition of mitotic cell cycle
GO:0006283; transcription-coupled nucleotide-excision repair
GO:0006294; nucleotide-excision repair, preincision complex assembly
GO:0006361; transcription initiation from RNA polymerase I promoter
GO:0006362; transcription elongation from RNA polymerase I promoter
GO:0006363; termination of RNA polymerase I transcription
GO:0006366; transcription from RNA polymerase II promoter
GO:0006367; transcription initiation from RNA polymerase II promoter
GO:0006368; transcription elongation from RNA polymerase II promoter
GO:0006370; 7-methylguanosine mRNA capping
GO:0006468; protein phosphorylation
GO:0007050; cell cycle arrest
GO:0008283; cell proliferation
GO:0030521; androgen receptor signaling pathway
GO:0042795; snRNA transcription from RNA polymerase II promoter
GO:0045893; positive regulation of transcription, DNA-templated
GO:0045944; positive regulation of transcription from RNA polymerase II promoter
GO:0051301; cell division

Cellular component:

GO:0005634; nucleus
GO:0005654; nucleoplasm
GO:0005675; holo TFIIH complex
GO:0005737; cytoplasm
GO:0005739; mitochondrion
GO:0048471; perinuclear region of cytoplasm

Function:

GO:0003713; transcription coactivator activity
GO:0004672; protein kinase activity
GO:0004674; protein serine/threonine kinase activity
GO:0004693; cyclin-dependent protein serine/threonine kinase activity
GO:0005515; protein binding
GO:0005524; ATP binding
GO:0008022; protein C-terminus binding
GO:0008094; DNA-dependent ATPase activity
GO:0008353; RNA polymerase II carboxy-terminal domain kinase activity
GO:0016301; kinase activity
GO:0050681; androgen receptor binding

Hide GO terms

Protein interactions and network

Protein-protein interacting partners in GenAge: TP53, ERCC2, E2F1, BRCA1, RPA1, HSP90AA1, ERCC3, ERCC5, AR, GTF2H2, APP, A2M, CCNA2, CDK1, HDAC2, ESR1, CDK7
STRING interaction network

Retrieve sequences for CDK7

Promoter: Promoter
ORF: ORF
CDS: CDS

Homologs in model organisms

Caenorhabditis elegans: cdk-7
Danio rerio: cdk7
Drosophila melanogaster: Cdk7
Mus musculus: Cdk7
Rattus norvegicus: Cdk7
Saccharomyces cerevisiae: KIN28
Schizosaccharomyces pombe: crk1

In other databases

GenAge model organism genes

A homolog of this gene for Caenorhabditis elegans is present as cdk-7
A homolog of this gene for Mus musculus is present as Cdk7