GenAge entry for FEN1 (Homo sapiens)
Gene name (HAGRID: 114)
- HGNC symbol
- FEN1
- Aliases
- FEN-1; MF1; RAD2
- Common name
- flap structure-specific endonuclease 1
Potential relevance to the human ageing process
- Main reason for selection
- Entry selected based on evidence showing that the gene product to be a target of genes previously linked to ageing
- Description
Involved in DNA processing, FEN1 has been associated with cancer progression [586]. A FEN1 role in ageing is unknown, but due to its interactions with WRN [584] and PCNA [588], FEN1 might, in theory, be involved in human ageing.
Cytogenetic information
- Cytogenetic band
- 11q12
- Location
- 61,792,637 bp to 61,797,242 bp
- Orientation
- Plus strand
Protein information
- Gene Ontology
-
Process: GO:0000722; telomere maintenance via recombination
GO:0000724; double-strand break repair via homologous recombination
GO:0006260; DNA replication
GO:0006281; DNA repair
GO:0006302; double-strand break repair
GO:0007613; memory
GO:0009650; UV protection
GO:0043137; DNA replication, removal of RNA primer
GO:0045876; positive regulation of sister chromatid cohesion
GO:0090305; nucleic acid phosphodiester bond hydrolysis
GO:0090502; RNA phosphodiester bond hydrolysis, endonucleolytic
Cellular component: GO:0000784; nuclear chromosome, telomeric region
GO:0005634; nucleus
GO:0005654; nucleoplasm
GO:0005730; nucleolus
GO:0005739; mitochondrion
GO:0005886; plasma membrane
GO:0016020; membrane
GO:0043234; protein complex
Function: GO:0003677; DNA binding
GO:0003684; damaged DNA binding
GO:0003690; double-stranded DNA binding
GO:0004519; endonuclease activity
GO:0004523; RNA-DNA hybrid ribonuclease activity
GO:0004527; exonuclease activity
GO:0005515; protein binding
GO:0008309; double-stranded DNA exodeoxyribonuclease activity
GO:0008409; 5'-3' exonuclease activity
GO:0017108; 5'-flap endonuclease activity
GO:0046872; metal ion binding
GO:0048256; flap endonuclease activity
Protein interactions and network
- Protein-protein interacting partners in GenAge
- WRN, BLM, EP300, GSK3B, TERF1, PCNA, APP, CCNA2, FOXO4, APEX1, CDK1
- STRING interaction network
Retrieve sequences for FEN1
Homologs in model organisms
- Caenorhabditis elegans
- crn-1
- Danio rerio
- fen1
- Drosophila melanogaster
- Fen1
- Mus musculus
- Fen1
- Rattus norvegicus
- Fen1
- Saccharomyces cerevisiae
- RAD27
- Schizosaccharomyces pombe
- rad2
In other databases
- GenAge model organism genes
- A homolog of this gene for Saccharomyces cerevisiae is present as RAD27
- LongevityMap
- This gene is present as FEN1
- CellAge gene expression
- This gene is present as FEN1