GenAge entry for IKBKB (Homo sapiens)

Entry selected based on evidence directly linking the gene product to ageing in a mammalian model organism

Gene name (HAGRID: 297)

HGNC symbol: IKBKB
Aliases: IKK2; NFKBIKB; IKK-beta; IKKB
Common name: inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase beta

Potential relevance to the human ageing process

Main reason for selection: Entry selected based on evidence directly linking the gene product to ageing in a mammalian model organism
Description: IKBKB regulates the degradation of the NFkB complex, including RELA, NFKB1 and NFKB2, and as such is involved in inflammation. Brain-specific IKBKB knockout mice live 23% longer. Conversely, viral activation in the hypothalamus activates NFkB and reduces lifespan [3260]. This suggest a potential role for IKBKB in ageing, though further studies are warranted.

Cytogenetic information

Cytogenetic band: 8p11.2
Location: 42,271,302 bp to 42,332,653 bp
Orientation: Plus strand

Display region using the UCSC Genome Browser (GRCh38/hg38)

Protein information

Gene Ontology

Process:

GO:0002223; stimulatory C-type lectin receptor signaling pathway
GO:0006468; protein phosphorylation
GO:0006954; inflammatory response
GO:0007249; I-kappaB kinase/NF-kappaB signaling
GO:0007252; I-kappaB phosphorylation
GO:0009615; response to virus
GO:0009653; anatomical structure morphogenesis
GO:0010803; regulation of tumor necrosis factor-mediated signaling pathway
GO:0030866; cortical actin cytoskeleton organization
GO:0033209; tumor necrosis factor-mediated signaling pathway
GO:0035509; negative regulation of myosin-light-chain-phosphatase activity
GO:0035666; TRIF-dependent toll-like receptor signaling pathway
GO:0038095; Fc-epsilon receptor signaling pathway
GO:0042325; regulation of phosphorylation
GO:0042501; serine phosphorylation of STAT protein
GO:0043066; negative regulation of apoptotic process
GO:0043123; positive regulation of I-kappaB kinase/NF-kappaB signaling
GO:0045087; innate immune response
GO:0045893; positive regulation of transcription, DNA-templated
GO:0045944; positive regulation of transcription from RNA polymerase II promoter
GO:0050852; T cell receptor signaling pathway
GO:0051092; positive regulation of NF-kappaB transcription factor activity
GO:0051403; stress-activated MAPK cascade
GO:0070423; nucleotide-binding oligomerization domain containing signaling pathway
GO:0070498; interleukin-1-mediated signaling pathway
GO:0071356; cellular response to tumor necrosis factor
GO:0090002; establishment of protein localization to plasma membrane
GO:1903140; regulation of establishment of endothelial barrier
GO:1903347; negative regulation of bicellular tight junction assembly

Cellular component:

GO:0005634; nucleus
GO:0005737; cytoplasm
GO:0005829; cytosol
GO:0008385; IkappaB kinase complex
GO:0009898; cytoplasmic side of plasma membrane
GO:0035631; CD40 receptor complex
GO:0045121; membrane raft

Function:

GO:0004672; protein kinase activity
GO:0004674; protein serine/threonine kinase activity
GO:0005515; protein binding
GO:0005524; ATP binding
GO:0008384; IkappaB kinase activity
GO:0019901; protein kinase binding
GO:0042803; protein homodimerization activity
GO:0046982; protein heterodimerization activity
GO:0097110; scaffold protein binding

Hide GO terms

Protein interactions and network

Protein-protein interacting partners in GenAge: TP53, IRS1, AKT1, NGFR, PRKCD, CREBBP, BCL2, HSP90AA1, NFKB1, TNF, HTT, PRKCA, PRKDC, FOXO3, RELA, MAPK14, JUN, NFKBIA, MTOR, CTNNB1, CDKN2A, PPP1CA, TP63, PPARG, TP73, IKBKB, RICTOR
STRING interaction network

Retrieve sequences for IKBKB

ORF: ORF
CDS: CDS

Homologs in model organisms

Danio rerio: ikbkb
Mus musculus: Ikbkb
Rattus norvegicus: Ikbkb

In other databases

GenAge model organism genes

A homolog of this gene for Mus musculus is present as Ikbkb