GenAge entry for JAK2 (Homo sapiens)

Gene name (HAGRID: 215)

HGNC symbol: JAK2
Aliases: JTK10
Common name: Janus kinase 2

Potential relevance to the human ageing process

Main reason for selection

Entry selected based on evidence showing that the gene product to be a target of genes previously linked to ageing

Description

JAK2 is a tyrosine kinase involved in cytokine receptor signalling. Disruption of JAK2 causes embryonic lethality due to the absence of definitive erythropoiesis [1175], however, knockdown or pharmacological inhibition of the JAK-STAT enhances satellite stem cell division potential, resulting in better muscle regeneration [3635].

Administrating JAK1/2 inhibitors to aged mice alleviates adipose and systemic inflammation, reduced frailty, and enhanced physical function. Upon JAK inhibition there was a reduction in inflammatory cytokines and chemokines. In addition, inhibition of the JAK pathway partially restored age-related decline in coordination [4344]. Inhibition of the JAK pathway using RNAi or JAK inhibitors in human cells suppresses the senescence associated secretory phenotype (SASP) [4344]. Its signalling functions and its association with a number of genes previously linked to ageing suggest JAK2 may play some role in ageing, even though a direct association of JAK2 with human ageing has not been established.

Cytogenetic information

Cytogenetic band: 9p24
Location: 4,985,245 bp to 5,128,183 bp
Orientation: Plus strand

Display region using the UCSC Genome Browser (GRCh38/hg38)

Protein information

Gene Ontology

Process:

GO:0000165; MAPK cascade
GO:0000186; activation of MAPKK activity
GO:0002250; adaptive immune response
GO:0006468; protein phosphorylation
GO:0006915; apoptotic process
GO:0006919; activation of cysteine-type endopeptidase activity involved in apoptotic process
GO:0006928; movement of cell or subcellular component
GO:0007165; signal transduction
GO:0007167; enzyme linked receptor protein signaling pathway
GO:0007186; G-protein coupled receptor signaling pathway
GO:0007204; positive regulation of cytosolic calcium ion concentration
GO:0007259; JAK-STAT cascade
GO:0007260; tyrosine phosphorylation of STAT protein
GO:0007262; STAT protein import into nucleus
GO:0007498; mesoderm development
GO:0007596; blood coagulation
GO:0008285; negative regulation of cell proliferation
GO:0008631; intrinsic apoptotic signaling pathway in response to oxidative stress
GO:0010667; negative regulation of cardiac muscle cell apoptotic process
GO:0010811; positive regulation of cell-substrate adhesion
GO:0014068; positive regulation of phosphatidylinositol 3-kinase signaling
GO:0016477; cell migration
GO:0018108; peptidyl-tyrosine phosphorylation
GO:0019221; cytokine-mediated signaling pathway
GO:0022408; negative regulation of cell-cell adhesion
GO:0030041; actin filament polymerization
GO:0030154; cell differentiation
GO:0030218; erythrocyte differentiation
GO:0030335; positive regulation of cell migration
GO:0031103; axon regeneration
GO:0031959; mineralocorticoid receptor signaling pathway
GO:0032024; positive regulation of insulin secretion
GO:0032496; response to lipopolysaccharide
GO:0032516; positive regulation of phosphoprotein phosphatase activity
GO:0032731; positive regulation of interleukin-1 beta production
GO:0032760; positive regulation of tumor necrosis factor production
GO:0033160; positive regulation of protein import into nucleus, translocation
GO:0033194; response to hydroperoxide
GO:0033209; tumor necrosis factor-mediated signaling pathway
GO:0034612; response to tumor necrosis factor
GO:0035409; histone H3-Y41 phosphorylation
GO:0035556; intracellular signal transduction
GO:0035722; interleukin-12-mediated signaling pathway
GO:0038083; peptidyl-tyrosine autophosphorylation
GO:0042127; regulation of cell proliferation
GO:0042503; tyrosine phosphorylation of Stat3 protein
GO:0042506; tyrosine phosphorylation of Stat5 protein
GO:0042508; tyrosine phosphorylation of Stat1 protein
GO:0042517; positive regulation of tyrosine phosphorylation of Stat3 protein
GO:0042523; positive regulation of tyrosine phosphorylation of Stat5 protein
GO:0042977; activation of JAK2 kinase activity
GO:0042981; regulation of apoptotic process
GO:0043388; positive regulation of DNA binding
GO:0043392; negative regulation of DNA binding
GO:0043524; negative regulation of neuron apoptotic process
GO:0043547; positive regulation of GTPase activity
GO:0045087; innate immune response
GO:0045429; positive regulation of nitric oxide biosynthetic process
GO:0045597; positive regulation of cell differentiation
GO:0045822; negative regulation of heart contraction
GO:0046677; response to antibiotic
GO:0046777; protein autophosphorylation
GO:0048008; platelet-derived growth factor receptor signaling pathway
GO:0050727; regulation of inflammatory response
GO:0050729; positive regulation of inflammatory response
GO:0050731; positive regulation of peptidyl-tyrosine phosphorylation
GO:0050867; positive regulation of cell activation
GO:0051091; positive regulation of sequence-specific DNA binding transcription factor activity
GO:0051770; positive regulation of nitric-oxide synthase biosynthetic process
GO:0060333; interferon-gamma-mediated signaling pathway
GO:0060334; regulation of interferon-gamma-mediated signaling pathway
GO:0060396; growth hormone receptor signaling pathway
GO:0060397; JAK-STAT cascade involved in growth hormone signaling pathway
GO:0060399; positive regulation of growth hormone receptor signaling pathway
GO:0061180; mammary gland epithelium development
GO:0070671; response to interleukin-12
GO:0097191; extrinsic apoptotic signaling pathway
GO:0097296; activation of cysteine-type endopeptidase activity involved in apoptotic signaling pathway
GO:1902728; positive regulation of growth factor dependent skeletal muscle satellite cell proliferation
GO:1904037; positive regulation of epithelial cell apoptotic process
GO:1904707; positive regulation of vascular smooth muscle cell proliferation

Cellular component:

GO:0005634; nucleus
GO:0005654; nucleoplasm
GO:0005737; cytoplasm
GO:0005829; cytosol
GO:0005856; cytoskeleton
GO:0005901; caveola
GO:0016363; nuclear matrix
GO:0031234; extrinsic component of cytoplasmic side of plasma membrane
GO:0031904; endosome lumen
GO:0045121; membrane raft

Function:

GO:0004672; protein kinase activity
GO:0004713; protein tyrosine kinase activity
GO:0004715; non-membrane spanning protein tyrosine kinase activity
GO:0005088; Ras guanyl-nucleotide exchange factor activity
GO:0005102; receptor binding
GO:0005131; growth hormone receptor binding
GO:0005143; interleukin-12 receptor binding
GO:0005515; protein binding
GO:0005524; ATP binding
GO:0008022; protein C-terminus binding
GO:0019901; protein kinase binding
GO:0020037; heme binding
GO:0031702; type 1 angiotensin receptor binding
GO:0033130; acetylcholine receptor binding
GO:0035401; histone kinase activity (H3-Y41 specific)
GO:0042169; SH2 domain binding
GO:0042393; histone binding
GO:0043548; phosphatidylinositol 3-kinase binding
GO:0043560; insulin receptor substrate binding
GO:0046872; metal ion binding
GO:0051428; peptide hormone receptor binding

Hide GO terms

Protein interactions and network

Protein-protein interacting partners in GenAge: GHR, SHC1, PTPN11, STAT5B, STAT3, STAT5A, IRS1, PTPN1, EGFR, ERBB2, INSR, IL2RG, EPOR, BRCA1, HSP90AA1, EMD, GRB2, PTK2B, PTK2, FGFR1, MAP3K5, PIK3R1, HSPA8, JAK2, AGTR1
STRING interaction network

Retrieve sequences for JAK2

ORF: ORF
CDS: CDS

Homologs in model organisms

Danio rerio: jak2b
Mus musculus: Jak2
Rattus norvegicus: Jak2

In other databases

LongevityMap

This gene is present as JAK2

CellAge

This gene is present as JAK2