GenAge entry for LRP2 (Homo sapiens)

Gene name (HAGRID: 134)

HGNC symbol: LRP2
Aliases: gp330; DBS
Common name: low density lipoprotein receptor-related protein 2

Potential relevance to the human ageing process

Main reason for selection: Entry selected based on evidence showing that the gene product to be a target of genes previously linked to ageing
Description: LRP2 binds CLU and other ligands and may play a role in cholesterol homeostasis. It may also help regulate the release of parathyroid hormone [684]. Disruption of LRP2 in mice results in defective forebrain development [683]. Its role, if any, in human ageing is unclear.

Cytogenetic information

Cytogenetic band: 2q31.1
Location: 169,127,109 bp to 169,362,612 bp
Orientation: Minus strand

Display region using the UCSC Genome Browser (GRCh38/hg38)

Protein information

Gene Ontology

Process:

GO:0001523; retinoid metabolic process
GO:0003281; ventricular septum development
GO:0006486; protein glycosylation
GO:0006629; lipid metabolic process
GO:0006897; endocytosis
GO:0006898; receptor-mediated endocytosis
GO:0008283; cell proliferation
GO:0030900; forebrain development
GO:0035904; aorta development
GO:0042359; vitamin D metabolic process
GO:0042953; lipoprotein transport
GO:0060976; coronary vasculature development

Cellular component:

GO:0005764; lysosome
GO:0005765; lysosomal membrane
GO:0005768; endosome
GO:0005783; endoplasmic reticulum
GO:0005794; Golgi apparatus
GO:0005886; plasma membrane
GO:0005905; clathrin-coated pit
GO:0016021; integral component of membrane
GO:0016324; apical plasma membrane
GO:0030139; endocytic vesicle
GO:0031526; brush border membrane
GO:0043235; receptor complex
GO:0070062; extracellular exosome

Function:

GO:0005041; low-density lipoprotein receptor activity
GO:0005509; calcium ion binding
GO:0005515; protein binding
GO:0017124; SH3 domain binding
GO:0042954; lipoprotein transporter activity

Hide GO terms

Protein interactions and network

Protein-protein interacting partners in GenAge: PLAU, APP, APOE, CLU
STRING interaction network

Retrieve sequences for LRP2

ORF: ORF
CDS: CDS

Homologs in model organisms

Caenorhabditis elegans: lrp-1
Danio rerio: lrp2a
Drosophila melanogaster: mgl
Mus musculus: Lrp2
Rattus norvegicus: Lrp2