GenAge entry for MED1 (Homo sapiens)

Gene name (HAGRID: 173)

HGNC symbol
MED1 
Aliases
PBP; TRAP220; RB18A; DRIP230; CRSP200; CRSP1; TRIP2; PPARGBP; PPARBP 
Common name
mediator complex subunit 1 

Potential relevance to the human ageing process

Main reason for selection
Entry selected based on indirect or inconclusive evidence linking the gene product to ageing in humans or in one or more model systems
Description

MED1 is a transcriptional coactivator involved in embryonic development and important for SP1 activity [785]. MED1-null mice die at embryonic stages [785]. Certain age-related pathologies, such as heart disease, may be related to PPARs [392], but it unclear whether MED1 is a major player in human ageing.

Cytogenetic information

Cytogenetic band
17q12
Location
39,404,285 bp to 39,451,274 bp
Orientation
Minus strand
Display region using the UCSC Genome Browser (GRCh38/hg38)

Protein information

Gene Ontology
Process: GO:0000122; negative regulation of transcription from RNA polymerase II promoter
GO:0000902; cell morphogenesis
GO:0001525; angiogenesis
GO:0001889; liver development
GO:0001892; embryonic placenta development
GO:0002088; lens development in camera-type eye
GO:0002154; thyroid hormone mediated signaling pathway
GO:0003222; ventricular trabecula myocardium morphogenesis
GO:0003406; retinal pigment epithelium development
GO:0006356; regulation of transcription from RNA polymerase I promoter
GO:0006367; transcription initiation from RNA polymerase II promoter
GO:0006590; thyroid hormone generation
GO:0006702; androgen biosynthetic process
GO:0007420; brain development
GO:0007595; lactation
GO:0010628; positive regulation of gene expression
GO:0010839; negative regulation of keratinocyte proliferation
GO:0016567; protein ubiquitination
GO:0030216; keratinocyte differentiation
GO:0030224; monocyte differentiation
GO:0030518; intracellular steroid hormone receptor signaling pathway
GO:0030521; androgen receptor signaling pathway
GO:0031100; animal organ regeneration
GO:0033148; positive regulation of intracellular estrogen receptor signaling pathway
GO:0033160; positive regulation of protein import into nucleus, translocation
GO:0033601; positive regulation of mammary gland epithelial cell proliferation
GO:0035050; embryonic heart tube development
GO:0035116; embryonic hindlimb morphogenesis
GO:0035162; embryonic hemopoiesis
GO:0035357; peroxisome proliferator activated receptor signaling pathway
GO:0035729; cellular response to hepatocyte growth factor stimulus
GO:0035855; megakaryocyte development
GO:0042789; mRNA transcription from RNA polymerase II promoter
GO:0043066; negative regulation of apoptotic process
GO:0044255; cellular lipid metabolic process
GO:0045444; fat cell differentiation
GO:0045618; positive regulation of keratinocyte differentiation
GO:0045648; positive regulation of erythrocyte differentiation
GO:0045665; negative regulation of neuron differentiation
GO:0045893; positive regulation of transcription, DNA-templated
GO:0045944; positive regulation of transcription from RNA polymerase II promoter
GO:0048821; erythrocyte development
GO:0048822; enucleate erythrocyte development
GO:0051726; regulation of cell cycle
GO:0060335; positive regulation of interferon-gamma-mediated signaling pathway
GO:0060744; mammary gland branching involved in thelarche
GO:0060745; mammary gland branching involved in pregnancy
GO:0060750; epithelial cell proliferation involved in mammary gland duct elongation
GO:0070318; positive regulation of G0 to G1 transition
GO:0070371; ERK1 and ERK2 cascade
GO:0070562; regulation of vitamin D receptor signaling pathway
GO:0071364; cellular response to epidermal growth factor stimulus
GO:0071383; cellular response to steroid hormone stimulus
GO:0097067; cellular response to thyroid hormone stimulus
GO:2000273; positive regulation of receptor activity
GO:2000347; positive regulation of hepatocyte proliferation
GO:2001141; regulation of RNA biosynthetic process
Cellular component: GO:0000151; ubiquitin ligase complex
GO:0000785; chromatin
GO:0005634; nucleus
GO:0005654; nucleoplasm
GO:0005730; nucleolus
GO:0016020; membrane
GO:0016592; mediator complex
GO:0032993; protein-DNA complex
Function: GO:0000978; RNA polymerase II core promoter proximal region sequence-specific DNA binding
GO:0000981; RNA polymerase II transcription factor activity, sequence-specific DNA binding
GO:0001047; core promoter binding
GO:0001104; RNA polymerase II transcription cofactor activity
GO:0003682; chromatin binding
GO:0003712; transcription cofactor activity
GO:0003713; transcription coactivator activity
GO:0004872; receptor activity
GO:0005515; protein binding
GO:0008134; transcription factor binding
GO:0016922; ligand-dependent nuclear receptor binding
GO:0030331; estrogen receptor binding
GO:0030374; ligand-dependent nuclear receptor transcription coactivator activity
GO:0030375; thyroid hormone receptor coactivator activity
GO:0031490; chromatin DNA binding
GO:0035257; nuclear hormone receptor binding
GO:0036033; mediator complex binding
GO:0042809; vitamin D receptor binding
GO:0042974; retinoic acid receptor binding
GO:0042975; peroxisome proliferator activated receptor binding
GO:0046966; thyroid hormone receptor binding
GO:0050693; LBD domain binding
GO:0061630; ubiquitin protein ligase activity
Hide GO terms

Protein interactions and network

Protein-protein interacting partners in GenAge
POU1F1, TP53, ATM, MYC, PARP1, PIN1, NR3C1, AR, MED1, MDM2, ESR1, PPARGC1A, PPARG
STRING interaction network
Protein-Protein network diagram for MED1

Retrieve sequences for MED1

ORF
ORF
CDS
CDS

Homologs in model organisms

Danio rerio
med1
Drosophila melanogaster
MED1
Mus musculus
Med1
Rattus norvegicus
Med1

Selected references

External links

EPD
ORF Accession
NM_004774
CDS Accession
NP_004765
OMIM
604311
HPRD
05055
Ensembl
MED1
UniProt/Swiss-Prot
MED1_HUMAN
GeneCards
MED1
Entrez Gene
5469
UniGene
702009
GenAtlas
MED1
Internet
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