GenAge entry for NFKBIA (Homo sapiens)

Entry selected based on evidence directly linking the gene product to ageing in a mammalian model organism

Gene name (HAGRID: 219)

HGNC symbol: NFKBIA
Aliases: IKBA; MAD-3; IkappaBalpha; NFKBI
Common name: nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha

Potential relevance to the human ageing process

Main reason for selection: Entry selected based on evidence directly linking the gene product to ageing in a mammalian model organism
Description: NFKBIA inhibits NF-kappa-B by forming a complex with it, and may be involved in inflammation, apoptosis, differentiation, and growth. Downregulation of NFKBIA with age appears to occur in the rat liver [871]. Transgenic mice expressing dominant-negative IkB, and exhibiting functional inhibition of NF-kB signaling in endothelial cells, were protected from age-related insulin resistance and vascular senescence and, displayed a prolonged lifespan. In addition, the mice had also decreased oxidative stress markers, increased muscle blood flow, enhanced active-phase locomotor activity, and aortic upregulation of mitochondrial sirtuin-related proteins [2115]. Whether NFKBIA plays a role in human ageing remains to be determined.

Cytogenetic information

Cytogenetic band: 14q13
Location: 35,401,510 bp to 35,404,754 bp
Orientation: Minus strand

Display region using the UCSC Genome Browser (GRCh38/hg38)

Protein information

Gene Ontology

Process:

GO:0000060; protein import into nucleus, translocation
GO:0002223; stimulatory C-type lectin receptor signaling pathway
GO:0006915; apoptotic process
GO:0007253; cytoplasmic sequestering of NF-kappaB
GO:0010745; negative regulation of macrophage derived foam cell differentiation
GO:0010875; positive regulation of cholesterol efflux
GO:0010888; negative regulation of lipid storage
GO:0016032; viral process
GO:0031663; lipopolysaccharide-mediated signaling pathway
GO:0032088; negative regulation of NF-kappaB transcription factor activity
GO:0032270; positive regulation of cellular protein metabolic process
GO:0032495; response to muramyl dipeptide
GO:0034142; toll-like receptor 4 signaling pathway
GO:0035994; response to muscle stretch
GO:0038095; Fc-epsilon receptor signaling pathway
GO:0042127; regulation of cell proliferation
GO:0042345; regulation of NF-kappaB import into nucleus
GO:0042994; cytoplasmic sequestering of transcription factor
GO:0043066; negative regulation of apoptotic process
GO:0043330; response to exogenous dsRNA
GO:0043392; negative regulation of DNA binding
GO:0045638; negative regulation of myeloid cell differentiation
GO:0045746; negative regulation of Notch signaling pathway
GO:0045944; positive regulation of transcription from RNA polymerase II promoter
GO:0050852; T cell receptor signaling pathway
GO:0051092; positive regulation of NF-kappaB transcription factor activity
GO:0070417; cellular response to cold
GO:0070427; nucleotide-binding oligomerization domain containing 1 signaling pathway
GO:0070431; nucleotide-binding oligomerization domain containing 2 signaling pathway
GO:0071345; cellular response to cytokine stimulus
GO:0071407; cellular response to organic cyclic compound
GO:0097421; liver regeneration

Cellular component:

GO:0005634; nucleus
GO:0005737; cytoplasm
GO:0005829; cytosol
GO:0005886; plasma membrane
GO:0033256; I-kappaB/NF-kappaB complex

Function:

GO:0005515; protein binding
GO:0008134; transcription factor binding
GO:0008139; nuclear localization sequence binding
GO:0019899; enzyme binding
GO:0031072; heat shock protein binding
GO:0031625; ubiquitin protein ligase binding
GO:0032403; protein complex binding
GO:0042802; identical protein binding
GO:0051059; NF-kappaB binding

Hide GO terms

Protein interactions and network

Protein-protein interacting partners in GenAge: TP53, NFKB2, HDAC3, NCOR1, PIN1, VCP, ABL1, NFKB1, UBE2I, TNF, PRKCA, RELA, HDAC1, MAPK14, PIK3R1, HDAC2, HOXB7, CLU, MTOR, NCOR2, IKBKB
STRING interaction network

Retrieve sequences for NFKBIA

Promoter: Promoter
ORF: ORF
CDS: CDS

Homologs in model organisms

Danio rerio: nfkbiaa
Drosophila melanogaster: cact
Mus musculus: Nfkbia
Rattus norvegicus: Nfkbia

In other databases

GenDR gene expression

A homolog of this gene for Mus musculus is present as Nfkbia

CellAge

This gene is present as NFKBIA