GenAge entry for PDPK1 (Homo sapiens)

Gene name (HAGRID: 87)

HGNC symbol: PDPK1
Aliases: PDK1
Common name: 3-phosphoinositide dependent protein kinase 1

Potential relevance to the human ageing process

Main reason for selection: Entry selected based on evidence showing that the gene product to be a target of genes previously linked to ageing
Description: PDPK1 phosphorylates and activates AKT1, among other proteins, and appears to play a role in signal transduction and development, maybe by mediating the activation of AKT1 by growth factors. The PDPK1 encodes three isoforms. In roundworms, PDPK1 has been associated with signals related to development and longevity [948]. Mice without PDPK1 die at embryonic stages, though mice with low levels of PDPK1 are viable and fertile despite a small body size [1633].

Cytogenetic information

Cytogenetic band: 16p13.3
Location: 2,537,964 bp to 2,603,190 bp
Orientation: Plus strand

Display region using the UCSC Genome Browser (GRCh38/hg38)

Protein information

Gene Ontology

Process:

GO:0002223; stimulatory C-type lectin receptor signaling pathway
GO:0003323; type B pancreatic cell development
GO:0006351; transcription, DNA-templated
GO:0006355; regulation of transcription, DNA-templated
GO:0006468; protein phosphorylation
GO:0006469; negative regulation of protein kinase activity
GO:0006972; hyperosmotic response
GO:0007173; epidermal growth factor receptor signaling pathway
GO:0010518; positive regulation of phospholipase activity
GO:0010594; regulation of endothelial cell migration
GO:0010667; negative regulation of cardiac muscle cell apoptotic process
GO:0016477; cell migration
GO:0018105; peptidyl-serine phosphorylation
GO:0018107; peptidyl-threonine phosphorylation
GO:0019722; calcium-mediated signaling
GO:0030036; actin cytoskeleton organization
GO:0030168; platelet activation
GO:0030512; negative regulation of transforming growth factor beta receptor signaling pathway
GO:0031295; T cell costimulation
GO:0032148; activation of protein kinase B activity
GO:0032869; cellular response to insulin stimulus
GO:0034122; negative regulation of toll-like receptor signaling pathway
GO:0035556; intracellular signal transduction
GO:0038095; Fc-epsilon receptor signaling pathway
GO:0043122; regulation of I-kappaB kinase/NF-kappaB signaling
GO:0043304; regulation of mast cell degranulation
GO:0043524; negative regulation of neuron apoptotic process
GO:0046777; protein autophosphorylation
GO:0048015; phosphatidylinositol-mediated signaling
GO:0048041; focal adhesion assembly
GO:0050852; T cell receptor signaling pathway
GO:0051281; positive regulation of release of sequestered calcium ion into cytosol
GO:0071364; cellular response to epidermal growth factor stimulus
GO:0090004; positive regulation of establishment of protein localization to plasma membrane
GO:0097191; extrinsic apoptotic signaling pathway
GO:1990416; cellular response to brain-derived neurotrophic factor stimulus

Cellular component:

GO:0005622; intracellular
GO:0005654; nucleoplasm
GO:0005737; cytoplasm
GO:0005829; cytosol
GO:0005886; plasma membrane
GO:0005925; focal adhesion
GO:0014069; postsynaptic density
GO:0016020; membrane
GO:0031410; cytoplasmic vesicle
GO:0042995; cell projection
GO:0043204; perikaryon

Function:

GO:0004674; protein serine/threonine kinase activity
GO:0004676; 3-phosphoinositide-dependent protein kinase activity
GO:0005158; insulin receptor binding
GO:0005515; protein binding
GO:0005524; ATP binding
GO:0016004; phospholipase activator activity
GO:0016301; kinase activity
GO:0019901; protein kinase binding
GO:0043274; phospholipase binding

Hide GO terms

Protein interactions and network

Protein-protein interacting partners in GenAge: AKT1, PRKCD, PDPK1, XRCC6, APP, MAPK8
STRING interaction network

Retrieve sequences for PDPK1

ORF: ORF
CDS: CDS

Homologs in model organisms

Danio rerio: pdpk1b
Mus musculus: Pdpk1
Rattus norvegicus: Pdpk1

In other databases

LongevityMap

This gene is present as PDPK1

CellAge

This gene is present as PDPK1