GenAge entry for PPP1CA (Homo sapiens)

Gene name (HAGRID: 227)

HGNC symbol: PPP1CA
Aliases: PP1A; PP-1A; PP1alpha; PPP1A
Common name: protein phosphatase 1, catalytic subunit, alpha isozyme

Potential relevance to the human ageing process

Main reason for selection: Entry selected based on evidence directly linking the gene product to ageing in a cellular model system
Description: PPP1CA is part of protein phosphatase 1 (PP1), which is involved in different cellular processes including cell division, protein synthesis, and synaptic plasticity. It has also been associated with oncogene-induced senescence [3344]. PP1 inhibition in mice was associated with prolonged memory, and old mice had preserved memory, which suggests that PP1, including PPP1CA, could play a role in cognitive ageing [1407]. PPP1CA cardiac-specific overexpression in mice resulted in premature heart failure [1408]. Further research is necessary to establish whether PPP1CA is related to human ageing.

Cytogenetic information

Cytogenetic band: 11q13
Location: 67,398,181 bp to 67,401,905 bp
Orientation: Minus strand

Display region using the UCSC Genome Browser (GRCh38/hg38)

Protein information

Gene Ontology

Process:

GO:0005977; glycogen metabolic process
GO:0005979; regulation of glycogen biosynthetic process
GO:0005981; regulation of glycogen catabolic process
GO:0006470; protein dephosphorylation
GO:0007049; cell cycle
GO:0016311; dephosphorylation
GO:0030324; lung development
GO:0032091; negative regulation of protein binding
GO:0032922; circadian regulation of gene expression
GO:0036496; regulation of translational initiation by eIF2 alpha dephosphorylation
GO:0042752; regulation of circadian rhythm
GO:0043153; entrainment of circadian clock by photoperiod
GO:0048754; branching morphogenesis of an epithelial tube
GO:0051301; cell division
GO:0060828; regulation of canonical Wnt signaling pathway
GO:1904886; beta-catenin destruction complex disassembly
GO:2001241; positive regulation of extrinsic apoptotic signaling pathway in absence of ligand

Cellular component:

GO:0000164; protein phosphatase type 1 complex
GO:0000784; nuclear chromosome, telomeric region
GO:0005634; nucleus
GO:0005654; nucleoplasm
GO:0005730; nucleolus
GO:0005737; cytoplasm
GO:0005829; cytosol
GO:0005886; plasma membrane
GO:0005911; cell-cell junction
GO:0042587; glycogen granule
GO:0043197; dendritic spine
GO:0043204; perikaryon
GO:0070062; extracellular exosome
GO:0070688; MLL5-L complex
GO:0072357; PTW/PP1 phosphatase complex

Function:

GO:0004721; phosphoprotein phosphatase activity
GO:0004722; protein serine/threonine phosphatase activity
GO:0005515; protein binding
GO:0008157; protein phosphatase 1 binding
GO:0016791; phosphatase activity
GO:0032403; protein complex binding
GO:0043021; ribonucleoprotein complex binding
GO:0046872; metal ion binding

Hide GO terms

Protein interactions and network

Protein-protein interacting partners in GenAge: TP53, ATM, HDAC3, AKT1, MYC, NCOR1, BRCA1, PTEN, BCL2, GSK3B, AR, RB1, GRB2, HDAC1, PTK2, CREB1, HSPA8, CDK1, MAX, MDM2, ESR1, DBN1, CSNK1E, ARNTL, CLOCK, SIRT7, C1QA, IKBKB
STRING interaction network

Retrieve sequences for PPP1CA

Promoter: Promoter
ORF: ORF
CDS: CDS

Homologs in model organisms

Caenorhabditis elegans: gsp-2
Danio rerio: ppp1cab
Drosophila melanogaster: Pp1-87B
Mus musculus: Ppp1ca
Rattus norvegicus: Ppp1ca