GenAge entry for XRCC5 (Homo sapiens)

Entry selected based on evidence directly linking the gene product to ageing in a mammalian model organism

Gene name (HAGRID: 112)

HGNC symbol: XRCC5
Aliases: KU80; KARP-1; Ku86; KUB2
Common name: X-ray repair complementing defective repair in Chinese hamster cells 5 (double-strand-break rejoining)

Potential relevance to the human ageing process

Main reason for selection: Entry selected based on evidence directly linking the gene product to ageing in a mammalian model organism
Description: XRCC5, or Ku80, is a helicase involved in DNA repair and chromatin remodelling [577]. It has been found associated with the telomeres [158] and with WRN [983]. XRCC5-null mice live about 38 weeks and appear to age prematurely [1490]. As such, XRCC5 may play a role in human ageing.

Cytogenetic information

Cytogenetic band: 2q35
Location: 216,109,297 bp to 216,206,293 bp
Orientation: Plus strand

Display region using the UCSC Genome Browser (GRCh38/hg38)

Protein information

Gene Ontology

Process:

GO:0000723; telomere maintenance
GO:0006302; double-strand break repair
GO:0006303; double-strand break repair via nonhomologous end joining
GO:0006310; DNA recombination
GO:0006351; transcription, DNA-templated
GO:0007420; brain development
GO:0008283; cell proliferation
GO:0032481; positive regulation of type I interferon production
GO:0032508; DNA duplex unwinding
GO:0042493; response to drug
GO:0045892; negative regulation of transcription, DNA-templated
GO:0048660; regulation of smooth muscle cell proliferation
GO:0050769; positive regulation of neurogenesis
GO:0060218; hematopoietic stem cell differentiation
GO:0071398; cellular response to fatty acid
GO:0071475; cellular hyperosmotic salinity response
GO:0071480; cellular response to gamma radiation
GO:0071481; cellular response to X-ray
GO:0075713; establishment of integrated proviral latency
GO:1904430; negative regulation of t-circle formation

Cellular component:

GO:0000783; nuclear telomere cap complex
GO:0000784; nuclear chromosome, telomeric region
GO:0005634; nucleus
GO:0005654; nucleoplasm
GO:0005730; nucleolus
GO:0005829; cytosol
GO:0005886; plasma membrane
GO:0016020; membrane
GO:0043564; Ku70:Ku80 complex
GO:0070419; nonhomologous end joining complex

Function:

GO:0003677; DNA binding
GO:0003684; damaged DNA binding
GO:0003690; double-stranded DNA binding
GO:0003691; double-stranded telomeric DNA binding
GO:0004003; ATP-dependent DNA helicase activity
GO:0005515; protein binding
GO:0005524; ATP binding
GO:0008022; protein C-terminus binding
GO:0031625; ubiquitin protein ligase binding
GO:0042162; telomeric DNA binding
GO:0044212; transcription regulatory region DNA binding
GO:0044822; poly(A) RNA binding
GO:0044877; macromolecular complex binding
GO:0051575; 5'-deoxyribose-5-phosphate lyase activity

Hide GO terms

Protein interactions and network

Protein-protein interacting partners in GenAge: TERT, ATM, WRN, MYC, EGFR, NBN, PARP1, BRCA1, RPA1, TOP2A, TOP1, UBE2I, CEBPA, TERF1, PRKDC, AR, XRCC5, PCNA, TERF2, XRCC6, BAX, HSF1, BMI1, TFAP2A, APEX1, POLA1, H2AFX, HOXB7, HOXC4, ESR1, ATR, SIRT6, PPARG, SIRT7, TP53BP1
STRING interaction network

Retrieve sequences for XRCC5

ORF: ORF
CDS: CDS

Homologs in model organisms

Caenorhabditis elegans: cku-80
Danio rerio: xrcc5
Drosophila melanogaster: Ku80
Mus musculus: Xrcc5
Rattus norvegicus: Xrcc5
Schizosaccharomyces pombe: pku80

In other databases

GenAge model organism genes

A homolog of this gene for Mus musculus is present as Xrcc5

LongevityMap

This gene is present as XRCC5