GenAge entry for A2M (Homo sapiens)
Gene name (HAGRID: 139)
- HGNC symbol
- A2M
- Aliases
- FWP007; S863-7; CPAMD5
- Common name
- alpha-2-macroglobulin
Potential relevance to the human ageing process
- Main reason for selection
- Entry selected based on indirect or inconclusive evidence linking the gene product to ageing in humans or in one or more model systems
- Description
A2M inhibits proteinases. Knockout mice are more resistant to endotoxins [702], though they have not been shown to live longer. In humans, A2M has been associated with neurodegenerative diseases [703], but a direct association with human ageing has not been established.
Cytogenetic information
- Cytogenetic band
- 12p13.31
- Location
- 9,067,708 bp to 9,115,962 bp
- Orientation
- Minus strand
Protein information
- Gene Ontology
-
Process: GO:0001869; negative regulation of complement activation, lectin pathway
GO:0002576; platelet degranulation
GO:0007597; blood coagulation, intrinsic pathway
GO:0010951; negative regulation of endopeptidase activity
GO:0022617; extracellular matrix disassembly
GO:0043547; positive regulation of GTPase activity
GO:0048863; stem cell differentiation
GO:0051056; regulation of small GTPase mediated signal transduction
Cellular component: GO:0005576; extracellular region
GO:0005829; cytosol
GO:0031093; platelet alpha granule lumen
GO:0070062; extracellular exosome
GO:0072562; blood microparticle
Show all GO termsFunction: GO:0002020; protease binding
GO:0004867; serine-type endopeptidase inhibitor activity
GO:0005096; GTPase activator activity
GO:0005102; receptor binding
GO:0005515; protein binding
GO:0019838; growth factor binding
GO:0019899; enzyme binding
GO:0019959; interleukin-8 binding
GO:0019966; interleukin-1 binding
GO:0043120; tumor necrosis factor binding
GO:0048306; calcium-dependent protein binding
And 1 more GO terms
Protein interactions and network
- Protein-protein interacting partners in GenAge
- NGF, GRB2, APP, APOE, A2M, H2AFX, LEP, TP63, CDC42, CDKN1A, CDK7
- STRING interaction network
Retrieve sequences for A2M
Homologs in model organisms
- Mus musculus
- A2mp
- Rattus norvegicus
- LOC100911545