GenAge entry for ERBB2 (Homo sapiens)

Gene name (HAGRID: 41)

HGNC symbol: ERBB2
Aliases: NEU; HER-2; CD340; HER2; NGL
Common name: erb-b2 receptor tyrosine kinase 2

Potential relevance to the human ageing process

Main reason for selection: Entry selected based on evidence showing that the gene product to be a target of genes previously linked to ageing
Description: A component of the NRG1-receptor complex, ERBB2 is considered an oncogene and it promotes cellular growth and survival [271]. Though it is not significantly active in adult tissues, ERBB2 has been linked to cancer and may be associated with age-related changes in the nervous system [273].

Cytogenetic information

Cytogenetic band: 17q12
Location: 39,699,978 bp to 39,728,662 bp
Orientation: Plus strand

Display region using the UCSC Genome Browser (GRCh38/hg38)

Protein information

Gene Ontology

Process:

GO:0000165; MAPK cascade
GO:0001934; positive regulation of protein phosphorylation
GO:0006351; transcription, DNA-templated
GO:0006468; protein phosphorylation
GO:0007165; signal transduction
GO:0007166; cell surface receptor signaling pathway
GO:0007167; enzyme linked receptor protein signaling pathway
GO:0007169; transmembrane receptor protein tyrosine kinase signaling pathway
GO:0007422; peripheral nervous system development
GO:0007507; heart development
GO:0007528; neuromuscular junction development
GO:0008045; motor neuron axon guidance
GO:0008283; cell proliferation
GO:0014065; phosphatidylinositol 3-kinase signaling
GO:0014066; regulation of phosphatidylinositol 3-kinase signaling
GO:0018108; peptidyl-tyrosine phosphorylation
GO:0030307; positive regulation of cell growth
GO:0032886; regulation of microtubule-based process
GO:0033088; negative regulation of immature T cell proliferation in thymus
GO:0038128; ERBB2 signaling pathway
GO:0042060; wound healing
GO:0042552; myelination
GO:0043406; positive regulation of MAP kinase activity
GO:0043547; positive regulation of GTPase activity
GO:0045727; positive regulation of translation
GO:0045765; regulation of angiogenesis
GO:0045785; positive regulation of cell adhesion
GO:0045943; positive regulation of transcription from RNA polymerase I promoter
GO:0045945; positive regulation of transcription from RNA polymerase III promoter
GO:0046777; protein autophosphorylation
GO:0046854; phosphatidylinositol phosphorylation
GO:0048015; phosphatidylinositol-mediated signaling
GO:0048709; oligodendrocyte differentiation
GO:0050679; positive regulation of epithelial cell proliferation
GO:0070372; regulation of ERK1 and ERK2 cascade
GO:0071363; cellular response to growth factor stimulus
GO:0071364; cellular response to epidermal growth factor stimulus
GO:0090314; positive regulation of protein targeting to membrane
GO:2000145; regulation of cell motility

Cellular component:

GO:0005634; nucleus
GO:0005737; cytoplasm
GO:0005886; plasma membrane
GO:0010008; endosome membrane
GO:0016021; integral component of membrane
GO:0016323; basolateral plasma membrane
GO:0016324; apical plasma membrane
GO:0043209; myelin sheath
GO:0043235; receptor complex
GO:0048471; perinuclear region of cytoplasm

Function:

GO:0001042; RNA polymerase I core binding
GO:0004713; protein tyrosine kinase activity
GO:0004714; transmembrane receptor protein tyrosine kinase activity
GO:0004716; signal transducer, downstream of receptor, with protein tyrosine kinase activity
GO:0004888; transmembrane signaling receptor activity
GO:0005088; Ras guanyl-nucleotide exchange factor activity
GO:0005515; protein binding
GO:0005524; ATP binding
GO:0008022; protein C-terminus binding
GO:0019838; growth factor binding
GO:0019903; protein phosphatase binding
GO:0042802; identical protein binding
GO:0043125; ErbB-3 class receptor binding
GO:0046934; phosphatidylinositol-4,5-bisphosphate 3-kinase activity
GO:0046982; protein heterodimerization activity
GO:0046983; protein dimerization activity

Hide GO terms

Protein interactions and network

Protein-protein interacting partners in GenAge: SHC1, IGF1R, PTPN11, STAT3, NRG1, IRS1, EGFR, ERBB2, EGF, PLCG2, PIN1, HSP90AA1, ABL1, GRB2, PTK2B, PTK2, PIK3R1, JAK2, ESR1, CTNNB1, STUB1
STRING interaction network

Retrieve sequences for ERBB2

Promoter: Promoter
ORF: ORF
CDS: CDS

Homologs in model organisms

Danio rerio: erbb2
Drosophila melanogaster: Egfr
Mus musculus: Erbb2
Rattus norvegicus: Erbb2

In other databases

LongevityMap

This gene is present as ERBB2

CellAge

This gene is present as ERBB2