GenAge entry for NFKB1 (Homo sapiens)

Gene name (HAGRID: 82)

HGNC symbol: NFKB1
Aliases: KBF1; p105; NFKB-p50; p50; NF-kappaB; NFkappaB; NF-kB1
Common name: nuclear factor of kappa light polypeptide gene enhancer in B-cells 1

Potential relevance to the human ageing process

Main reason for selection: Entry selected based on evidence linking the gene product to a pathway or mechanism linked to ageing
Description: NFKB1 is a component of the NF-kappa-B complex, involved in oxidative pathways and a myriad of other processes. Its role in ageing is unclear, even though NFKB1 appears to be related to age-related changes in inflammation and maybe in other age-related processes too [260]. In addition, age-relation changes in NF-kappa-B have been reported for numerous tissues [261]. In nfkb1-/- mice, both median and maximum lifespan are reduced (median is ~33% lower). The reduction in lifespan is also acompanied by multiple signs of premature ageing (hair loss or early greying, scruffy fur and cachexia, skin inflammation and delayed wound healing, thinning of the epidermis, lost neuromuscular coordination, premature body mass loss and loss of fat from inguinal, epididymal and mesenteric depots) [3544].

Cytogenetic information

Cytogenetic band: 4q24
Location: 102,501,329 bp to 102,617,302 bp
Orientation: Plus strand

Display region using the UCSC Genome Browser (GRCh38/hg38)

Protein information

Gene Ontology

Process:

GO:0000122; negative regulation of transcription from RNA polymerase II promoter
GO:0002223; stimulatory C-type lectin receptor signaling pathway
GO:0006366; transcription from RNA polymerase II promoter
GO:0006915; apoptotic process
GO:0006954; inflammatory response
GO:0007249; I-kappaB kinase/NF-kappaB signaling
GO:0010629; negative regulation of gene expression
GO:0010744; positive regulation of macrophage derived foam cell differentiation
GO:0010884; positive regulation of lipid storage
GO:0010956; negative regulation of calcidiol 1-monooxygenase activity
GO:0010957; negative regulation of vitamin D biosynthetic process
GO:0031293; membrane protein intracellular domain proteolysis
GO:0032269; negative regulation of cellular protein metabolic process
GO:0032375; negative regulation of cholesterol transport
GO:0032481; positive regulation of type I interferon production
GO:0035994; response to muscle stretch
GO:0038061; NIK/NF-kappaB signaling
GO:0038095; Fc-epsilon receptor signaling pathway
GO:0043066; negative regulation of apoptotic process
GO:0045083; negative regulation of interleukin-12 biosynthetic process
GO:0045087; innate immune response
GO:0045893; positive regulation of transcription, DNA-templated
GO:0045944; positive regulation of transcription from RNA polymerase II promoter
GO:0050728; negative regulation of inflammatory response
GO:0050852; T cell receptor signaling pathway
GO:0051092; positive regulation of NF-kappaB transcription factor activity
GO:0051403; stress-activated MAPK cascade
GO:0071222; cellular response to lipopolysaccharide
GO:0071260; cellular response to mechanical stimulus
GO:0071316; cellular response to nicotine
GO:0071347; cellular response to interleukin-1
GO:0071354; cellular response to interleukin-6
GO:0071359; cellular response to dsRNA
GO:0071375; cellular response to peptide hormone stimulus
GO:0090263; positive regulation of canonical Wnt signaling pathway
GO:1900127; positive regulation of hyaluronan biosynthetic process
GO:2000630; positive regulation of miRNA metabolic process

Cellular component:

GO:0005634; nucleus
GO:0005654; nucleoplasm
GO:0005737; cytoplasm
GO:0005739; mitochondrion
GO:0005829; cytosol
GO:0033256; I-kappaB/NF-kappaB complex

Function:

GO:0000975; regulatory region DNA binding
GO:0000976; transcription regulatory region sequence-specific DNA binding
GO:0000977; RNA polymerase II regulatory region sequence-specific DNA binding
GO:0000980; RNA polymerase II distal enhancer sequence-specific DNA binding
GO:0001205; transcriptional activator activity, RNA polymerase II distal enhancer sequence-specific binding
GO:0001227; transcriptional repressor activity, RNA polymerase II transcription regulatory region sequence-specific binding
GO:0003682; chromatin binding
GO:0003700; transcription factor activity, sequence-specific DNA binding
GO:0005515; protein binding
GO:0008134; transcription factor binding
GO:0042802; identical protein binding
GO:0042803; protein homodimerization activity
GO:0042805; actinin binding
GO:0044212; transcription regulatory region DNA binding
GO:0046982; protein heterodimerization activity

Hide GO terms

Protein interactions and network

Protein-protein interacting partners in GenAge: TXN, E2F1, NFKB2, STAT3, STAT5A, HDAC3, NCOR1, PARP1, VCP, NR3C1, NFKB1, CEBPB, EP300, PML, GSK3B, RELA, HDAC1, SP1, HMGB1, TFAP2A, HDAC2, NFKBIA, CLU, CTNNB1, TP63, PPARGC1A, PPARG, TP53BP1, NCOR2, IKBKB
STRING interaction network

Retrieve sequences for NFKB1

ORF: ORF
CDS: CDS

Homologs in model organisms

Drosophila melanogaster: Rel
Mus musculus: Nfkb1
Rattus norvegicus: Nfkb1

In other databases

GenAge model organism genes

A homolog of this gene for Mus musculus is present as Nfkb1

LongevityMap

This gene is present as NFKB1